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Neuroscience I Test 3 > Pharmacology Capstone > Flashcards

Pharmacology Capstone Flashcards

1
Q

Sympathetic Innervation to Cardiac and Smooth M

A

Preganglionic: ACh to nicotinic R
Postganglionic: NE to alpha and beta R

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2
Q

Sympathetic Innervation to Renal Vascular SM

A

Preganglionic: ACh to nicotinic R
Postganglionic: dopamine to dopamine R

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3
Q

Parasympathetic Innervation of Cardiac and Smooth Muscle

A

Long Preganglionic: ACh to Nicotinic R

Short postganglionic: ACh to Muscarinic R

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4
Q

M2 and M3 receptors

A

Smooth muscle mAChRs–M2 R is predominant cardiac M mAChR

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5
Q

End result of alpha 1 receptor activation

A

Muscle contraction

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6
Q

Activation of alpha 2 receptor

A

Vascular SM contraction, decreased insulin secretion, dec release of NE

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7
Q

Activation of beta 1 receptors

A

Inc force and rate of heart contraction

AV nodal conduction velocity

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8
Q

Activation B2 receptor

A

Vascular, bronchial, genitourinary, and GI SM to relax

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9
Q

Activation of of B3 receptor

A

Lipolysis

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10
Q

Alpha 1 receptor

A
  • act thru Gq: inc PLC, IP3/DAG
  • Epi>NE
  • acts on vascular SM, GU SM, liver, intestinal SM
  • responses: contraction, inc contractile force
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11
Q

Alpha 2 receptor

A
  • Gi: dec adenylyl cyclase
  • Epi>NE
  • found presynaptically in CNS, dec insulin secretion, dec release of NE
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12
Q

Beta 1 receptor

A
  • Gs: inc adenylyl cyclase
  • Epi=NE
  • heart: inc force of contraction
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13
Q

Beta 2 receptor

A
  • Gs: inc adenylyl cyclase
  • Epi>NE
  • SM: relaxation
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14
Q

Beta 3 receptor

A
  • Gs: inc adenylyl cyclase
  • NE>Epi
  • adipose tissue: Lipolysis
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15
Q

Innervation of Sweat Glands

A

Preganglionic: release of ACh to nicotinic R
Postganglionic: release of ACh to muscarinic R on sweat glands

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16
Q

Endothelium Derived Relaxing Factor

A

SM of blood vessels is not innervated by PS neurons but is innervated by sympathetic neurons

  • blood vessel endothelial cells release a short lived vasodilator called EDRF, now known as NO
  • in response to AP, PS neurons release ACh
    • the circulating ACh activates mAChRs
    • NO is produced by endothelial cells and diffuses back to SM cells surrounding blood vessels which it causes relaxation
17
Q

Rule about alpha 1 adrenergic Rs

A
  • stimulate contraction of all SM
    • vascular SM–vasoconstriction
    • glandular SM–secretion
18
Q

Beta 2 adrenergic receptor Rule

A
  • relax SM

- vascular SM–vasodilation

19
Q

Muscarinic Rs rule

A
  • contract SM

- NO acts on them to relax and vasodilate vessels

20
Q

Parasympathetic Tone

A

Rest and digest
-cholinergic effects

Salivation
Lacrimation
Pupil constriction
Dec in HR
Urination
Inc secretions
Inc GI track motility
21
Q

Sympathetic tone

A

Fight or flight
Adrenergic

Pupil dilation
Inc in HR
Urinary retention
Dec secretions
dec GI track motility

Neuroscience I Test 3 (20 decks)

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