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5. Metabolismo de la glucosa y lipidos > 5.1.4 Agonistas del receptor PPARγ: PIOGLITAZONA > Flashcards

5.1.4 Agonistas del receptor PPARγ: PIOGLITAZONA Flashcards

1
Q

Agonista del receptor PPARg

A

Pioglitazona

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2
Q

¿Qué provoca el agonsimo del receptor PPARg?

A

Disminución de la resisetncia a insulina de tejidos periféricos y en hígado

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3
Q

Metabaolismo de Pioglitazona

A

Hepático CYP28 y CYP3A4

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4
Q

Reacciones adversa de la pioglitazona

A

Aumento de peso (2-4kg), edema, insuficiencia cardpiaca, fracturas óseas y falla cardíaca

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5
Q

Efecto sobre los lípidos

A

Disminuye triglicéridos y colesterol; auemnta HDL y LDL

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6
Q

Porcentaje de HbA1c que disminuye

A

0.5- 1.4

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5. Metabolismo de la glucosa y lipidos (15 decks)

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