Excitation-Contraction Coupling

Question 1

What situations may stop the cross-bridge cycling contraction in skeletal muscle?

Answer 1

• withdrawal of Ca ▶️ normal resting

- depletion of ATP ▶️ rigor mortis

Question 2

Wha is the function of SERCA?

Answer 2

Pumps Ca back into the SR from cytosol ▶️ terminate contraction

*sarcoplasmic endoplasmic reticulum calcium ATPase (SERCA)

Question 3

a dysfunction in the titin protein is associated with what condition?

Answer 3

Dilated and restrictive cardiomyopathy