Autoimmunity Flashcards Preview

Integrated > Autoimmunity > Flashcards

Flashcards in Autoimmunity Deck (10)
Loading flashcards...
1
Q

Causes

A

Less Treg cells, overactive T cells, oestrogen, infection, trauma, smoking

2
Q

Coeliac

A

Tissue transglutamase alters gluten so it binds to HLA
Il-15 expressed which makes intraepithelial lymphocytes kill enterocytes
Can get dermatitis, gastritis and colitis
Increased lymphoma risk

3
Q

Rheumatoid Arthritis

A

Protein citrullinated

4
Q

Hashimotos Thyroiditis

A

Hypothyroidism
Abs to thryoglobulin destroy follicles
Chronic inflam
Increased risk of lymphoma and papillary carcinoma

5
Q

Grave’s Disease

A

Hyperthyroidism
Abs to anti-TSH
Stimulated thyroid gland
Hyperplasia of epithelium

6
Q

Myasthenia Gravis

A

Abs block ACh receptors

7
Q

Pernicious Anaemia

A

Abs block intrinsic factor

B12 isn’t absorbed

8
Q

SLE

A

Apoptosis fails
ANA Abs attack nuclei remains
Symps= inflammed kidney, fatigue, seizures, rashes, arthralgia

9
Q

Scleroderma

A

Ischamia and fibrosis thickens+tightens skin

10
Q

Vasculitis

A

Anti-neutrophil Abs cause inflam in vessels

Can get granulomas