Virus pathologies

Question 1

Colorado tick fever: saddleback fever pattern; travel to mountain West

Answer 1

Colorado tick fever virus

Question 2

CMV infectious mononucleosis: heterophile Ab negative; Owl’s eyes cells
Congenital systemic CMV: deafness

Answer 2

Cytomegalovirus (CMV; HHV-5)

Question 3

exanthem subitum (aka roseola):  rash that develops after a fever resolves
heterophile Ab negative mononuceosis

Answer 3

HHV-6 & HHV-7

Question 4

EBV infectious mononucleosis: Heterophile Ab positive mono
Burkitt lymphoma: t(8:14)
Hodgkin & non-Hodgkin lymphoma
nasopharyngeal lymphoma
X-linked lymphoproliferative disease: inherited mutation in SAP adapeter

Answer 4

Epstein Barr virus (EBV; HHV-4)

Question 5

in immunocompromised patients only: Kaposi sarcoma, primary effusion lymphoma, multifocal Castlemans disease

Answer 5

Kaposi sarcoma herpes virus (KSHV; HHV-8)

Question 6

erythema infectiosum: fiery red rash on cheek. Transient aplastic crisis: in patients with underlying anemia

Answer 6

parvovirus B19

Question 7

Acute T cell lymphoma / leukemia (ATL): Viral transcription factor Tax drives proliferation; blocks apoptosis.
HAM/TSP: Inflammation on the spine

Answer 7

Human T lymphotrophi virus -1 (HTLV-1; related: HTLV-2)

Question 8

Acquired immunodeficiency syndrome: depletion of CD4 T cells allows opportunistic infections

Answer 8

Human immunodeficiency virus -1 (HIV-1; related: HIV-2)

Question 9

Hemorrhagic fever

Answer 9

Ebola virus (EBOV)