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STEP 2 > ED: Drug Side Effects > Flashcards

ED: Drug Side Effects Flashcards

1
Q

ACE Inhibitors

A

Cough, rash, proteinuria, angioedema, taste changes, teratogenic effects

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2
Q

Amantadine

A

Ataxia, livedo reticularis

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3
Q

Aminoglycosides

A

Ototoxicity, nephrotoxicity (acute tubular necrosis)

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4
Q

Amiodarone

A

Acute: AV block, hypotension, bradycardia. Chronic: pulmonary fibrosis, peripheral deposition leading to bluish discoloration, arrhtyhmias, hypo/hyperthyroidism, corneal deposition

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5
Q

Amphotericin

A

Fevers/rigors, nephrotoxicity, bone marrow suppression, anemia

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6
Q

Antipsychotics

A

Sedation, acute dystonic reaction, akathisia, parkinsonism, tardive dyskinesia, NMS

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7
Q

Azoles

A

Inhibition of P-450 enzymes

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8
Q

AZT

A

Thrombocytopenia, megaloblastic anemia

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9
Q

Beta Blockers

A

Asthma exacerbation, masking of hypoglycemia, impotence, bradycardia, AV block, CHF

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10
Q

Benzodiazepines

A

Sedation, dependence, respiratory depression

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11
Q

Bile acid resins

A

GI upset, malabsorption of vitamins and medications

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12
Q

Carbamazepine

A

Induction of P450 enzymes, agranulocytosis, aplastic anemia, liver toxicity

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13
Q

Calcium channel blockers

A

Peripheral edema, constipation, cardiac depression

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14
Q

Chloramphenicol

A

Gray baby syndrome, aplastic anemia

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15
Q

Cisplatin

A

Nephrotoxicity, acoustic nerve damage

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16
Q

Clonidine

A

Dry mouth; severe rebound headache and hypertension

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17
Q

Clozapine

A

Agranulocytosis

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18
Q

Corticosteroids

A

Mania; hyperglycemia (acute), immunosuppression, bone mineral loss, thinning of skin, easy bruising, myopathy, cataracts (chronic)

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19
Q

Cyclophosphamide

A

Myelosuppression, hemorrhagic cystitis

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20
Q

Digoxin

A

GI disturbance, yellow visual changes, arrhythmias

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21
Q

Doxorubicin

A

Cardiotoxicity (cardiomyopathy)

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22
Q

Ethyl alcohol

A

Acidosis, renal dysfunction, CNS depression

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23
Q

Fluoroquinolones

A

Cartilage damage in children; achilles tendon rupture in adults

24
Q

Furosemide

A

Ototoxicity, hypokalemia, nephritis, gout

25
Q

Gemfibrozil

A

Myositis, reversible increase in LFTs

26
Q

Halothane

A

Hepatotoxicity, malignant hyperthermia

27
Q

HCTZ

A

Hypokalemia, hyponatremia, hyperglycemia, hyperlipidemia, hyperuricemia, hypercalcemia (hyperGLUC)

28
Q

Statins

A

Myositis, reversible increase in LFTs

29
Q

Hydralazine

A

Drug-induced SLE

30
Q

Hydroxychloroquine

A

Retinopathy

31
Q

INH

A

Peripheral neuropathy (prevent with pyridoxine/vitamin B6), hepatotoxicity, inhibition of P450s, seizures with overdose, hemolysis in G6PD deficiency

32
Q

MAOIs

A

Hypertensive tyramine reaction, serotonin syndrome (with meperidine)

33
Q

Methanol

A

Blindness, ion-gap metabolic acidosis

34
Q

Methotrexate

A

Hepatic fibrosis, pneumonitis, anemia

35
Q

Methyldopa

A

+ coombs test, drug induced SLE

36
Q

Metronidazole

A

Disulfiram reaction, vestibular dysfunction, metallic taste

37
Q

Niacin

A

Cutaneous flushing

38
Q

Nitroglycerin

A

Hypotension, tachycardia, headache, tolerance

39
Q

Penicillamine

A

Drug-induced SLE

40
Q

Penicillin/Beta Lactams

A

Hypersensitivity Reactions

41
Q

Phenytoin

A

Nystagmus, diplopia, ataxia, arrhythmia (in toxic doses), gingival hyperplasia, hirsutism, teratogenic effects

42
Q

Prazosin

A

First dose hypotension

43
Q

Procainamide

A

Drug-induced SLE

44
Q

Propylthiouracil

A

Agranulocytosis, aplastic anemia

45
Q

Quinidine

A

Cinchonism (headache, tinnitus), thrombocytopenia, arryhthmias (torsades)

46
Q

Reserpine

A

Depression

47
Q

Rifampin

A

Induction of P450 enzymes; orange-red body secretions

48
Q

Salicylates

A

Fever; hyperventilation with respiratory alkalosis and metabolic acidosis; dehydration, diaphoresis, hemorrhagic gastritis

49
Q

SSRIs

A

Anxiety, sexual dysfunction, serotonin syndrome if taken with MAOIs

50
Q

Succinylcholine

A

Malignant hyperthermia, hyperkalemia

51
Q

TCAs

A

Sedation, coma, anticholinergic effects, seizures, QRS prolongation, arrhythmias

52
Q

Tetracyclines

A

Tooth discoloration, photosensitivity, Fanconi’s syndrome, GI distress

53
Q

Trimethoprim

A

Megaloblastic anemia, leukopenia, granulocytopenia

54
Q

Valproic Acid

A

Teratogenicity leads to neural tube defects; rare fatal hepatotoxicity

55
Q

Vancomycine

A

Nephrotoxicity, ototoxicity, red man syndrome (histamine release)

56
Q

Vinblastine

A

Severe myelosuppression

57
Q

Vincristine

A

Peripheral neuropathy, paralytic ileus

STEP 2 (27 decks)

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