Dr. Pelletier Flashcards
What does not change in the Hardy Weinberg Equilibrium?
Relative frequencies of genotypes
Hardy Weinberg Equation:
Genotypes = p^2+ 2pq+ q^2
p+q=1 (allele frequencies)
Five conditions for hardy weinberg:
- ) Large population
- ) Random mating
- ) No natural selection
- ) No mutation
- ) No gene flow in or out of population
What is positive assortment?
Mate selection based on similar ethnic backgrounds, physical traits, intelligence, religious background
What is consanguinity?
No MRCA more closely related than great-great grandparent
Issue with consanguinity?
More homozygotes for particular genes
What occurs with mutation?
Rate of introduction and rate of elimination cancel via natural selection having no impact on HW equation
Fitness:
Fitness= 1 - selection coefficient
What is the Founder Effect responsible for?
Population specific differences in the frequency of specific disease