embryology

Question 1

fetal erythropoiesis occurs in (and when)

Answer 1

1. yolk sac (3-8 weeks)
2. Liver (6 weeks - birth)
3. Spleen (10-28 weeks)
4. Bone marrow (18 weeks to adult)

Question 2

hemoglobin development - embryogenic globins

Answer 2

ζ and ε

Question 3

hemoglobin development - fetal hemoglobin

Answer 3

HbF (α2γ2)

Question 4

hemoglobin development - adult hemoglobin

Answer 4

HbA1 (α2β2)

Question 5

HBF is the fetal hemoglobin because (relative function)

Answer 5

HbF has higher affinity for 02 due to less avid binding of 2,3-BPG allowing HbF to extract 02 from maternal hemoglobin (HbA1 and HbA2) across the placenta

Question 6

hemoglobin development - α starts approximately at

Answer 6

3 weeks (and platue at 12)

Question 7

hemoglobin development - γ starts approximately at

Answer 7

3 weeks –> platue at 12 –> decrease at 35

Question 8

hemoglobin development - β starts approximately at

Answer 8

3 weeks –> platue at 12 weeks after pregnancy

Question 9

HbA2

Answer 9

α2δ2

Question 10

fetal erythropoiesis occurs in (and when)

Answer 10

1. yolk sac (3-8 weeks)
2. Liver (6 weeks - birth)
3. Spleen (10-28 weeks)
4. Bone marrow (18 weeks to adult)