Blood transfusion reaction

Question 1

Packed RBCs - dosage effect

Answer 1

increase Hb and O2 carrying capacity

Question 2

Packed RBCs - clinical use

Answer 2

1. acute blood loss

2. severe anemia

Question 3

Platelets transfusion - clinical use

Answer 3

stop significant bleeding (thrombocytopenia, qualitative platelet defects)

Question 4

Platelets transfusion - dosage effect

Answer 4

increases platelet count (5000mm3/unit)

Question 5

Fresh frozen plasma - dosage effect

Answer 5

increase coagulation factor levels

Question 6

Fresh frozen plasma - clinical use

Answer 6

1. DIC
2. Cirrhosis
3. immediate warfarin reversal

Question 7

Cryoprecipitate - dosage effect

Answer 7

contains: 1. fibrinogen 2. fibronectin

3. VWF 4. factor VIII 5. factor XIII

Question 8

Cryoprecipitate - clinical use

Answer 8

coagulation factor deficiencies involving fibrinogen and factor VIII

Question 9

blood transfusion risks

Answer 9

1. infection transmission (low)
2. transfusion reaction
3. iron overload
4. hypocalcemia
5. hyperkalemia

Question 10

blood transfusion risks - hyperkalemia (mechanism)

Answer 10

RBCs may lyse in in old blood units

Question 11

blood transfusion risks - hypocalcemia (mechanism)

Answer 11

citrate is a Ca2+ chelator