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Pulmonary > Cancer Pharmacology > Flashcards

Cancer Pharmacology Flashcards

1
Q

Drugs that inhibit DNA synthesis

A

Doxorubicin (intercalater, radicals, topo ii), Etoposide (topoII), Gemcitabine, Irinotecan, Topotecan (topoI)

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2
Q

Drugs that affect existing DNA

A

Carboplatin, Cisplatin (crosslinks), Cyclophosphamide, Ifosfamide (alkylators)

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3
Q

Drugs that inhibit microtubules

A

Docetaxel, Paclitaxel (inhibit depolymerization), Vincristine, Vinorelbine

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4
Q

Ameliorates Cisplatin toxicity

A

Amifostine

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5
Q

Ameliorates Doxorubicin toxicity

A

Dexrazoxane

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6
Q

Ameliorates Cyclophosphamide and Ifosfamide toxicity

A

MESNA (protects from acrolein)

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7
Q

Dose limiting toxicity of Cisplatin

A

Nephro and Ototoxicity

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8
Q

Dose limiting toxicity of Doxorubicin

A

Cardiotoxicity

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9
Q

Chemotherapy-induced peripheral toxicity from what drugs

A

Taxanes (Docetaxel, Paclitaxel); Vinka alkaloids (Vincristine, Vinorelbine); and Platins (Cisplatin more than Carboplatin)

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10
Q

Which drugs target EGFR del19/21subs

A

Afatinib, Erlotinib, Gefitinib

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11
Q

Which drugs target ALK

A

Alectinib, Ceritinib, Crizotinib (also HGFR mutation)

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12
Q

Which drugs target VEGF or VEGFR

A

Bevacizumab (VEGF) and Ramucirumab (VEGFR)

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13
Q

Which drugs target PD-1

A

Nivolumab and Pembrolizumab

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14
Q

Which drugs target EGFR

A

Necitumumab and Panitumumab

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15
Q

What drug targets EGFR-T790M mutation

A

Osimertinib (most common mutation in TKs)

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16
Q

How do mabs work

A

IV infusion and kill by ADCC, CDC, and initiation for apoptosis

17
Q

What CYP metabolizes TKIs

A

CYP3A4 (Imatinib mod inhibitor) some P-glycoproteins

18
Q

What drug targets BRAF V600E mutations

A

VEMURAFENIB, DABRAFENIB, and TRAMETINIB

19
Q

EGFR TKIs have what common adverse effect (other TKIs to lesser degree)

A

Rash (treat with steroid, sunscreen, antimicrobial)

20
Q

VEGF targeted therapies have what side effects

A

Bleeding (Bevacizumab), Increased thrombosis, CV toxicity, and hypertension

21
Q

PD-1 inhibitors have what side effects

A

Rash, GI toxicity, Liver toxicity, and ENDOCRINOPATHIES

22
Q

Targeted therapies treat what type of cancer

A

Adenocarcinoma

23
Q

Most common mutation in non-smokers

A

KRAS

24
Q

What genetic testing is indicated in adenocarcinoma

A

EGFR and ALK

25
Q

Standard treatment for SCLC

A

Etoposide+Cisplatin or carboplatin

26
Q

Standard treatment for NSCLC

A

Cisplatin and paclitaxel, gemcitibine, docetaxel, vinorelbine, irinotecan, or pemetrexed

27
Q

DHFR inhibitor

A

pemetrexed (leucovorin rescue)

28
Q

Side effect of vincristine

A

SIADH

29
Q

Bevacizumab should not be used in what type of cancer

A

NSCLC specifically squamous

Pulmonary (6 decks)

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