Bone in Class Presentation Flashcards
Bone malignancies are fairly uncommon. What is one common?
liomyomas of the uterus (especially in AA women)
as well as lipomas
When you see mixed osteolytic and osteoblastic lesions in a female, think:
metastatic breast cancer
What patient population is common for osteosarcoma?
mostly children and some older than 60
A positive TTF-1 indicates what?
adenocarcinoma of the lung
GATA-3 is positive in what?
breast tumors and urothelial bladder tumors
What metastatic cancers to bone have blastic/sclerotic lesions (hyper dense-whiter)?
prostate (induce bone growth)
What metastatic cancers to bone have purely lytic lesions (blacker)?
kidney, thyroid, lung
Ewing’s sarcomas are almost always positive for what?
CD99 (not specific)
Other tests for Ewing’s sarcoma?
a FISH-based for 22q12 rearrangement and a PCR-based test for the discrimination of the Type 1 and Type 2 forms of the EWS-FLI1 translocations
Common situational cause of rickets?
mom has two children and the earlier born one doesnt get as much breast milk once the other is born
What is the defect in osteogenesis imperfecta?
type 1 collagen
Paget disease is a disease of _____
osteoclasts
Possible cause of Paget disease?
viral infection (paramyxovirus) in association with genetic susceptibility
What are the three phases of Paget disease?
1) lytic (incipient active)- dominated by osteoclast activity
2) mixed (active)- balanced osteoblast/clast activity
3) sclerotic/blastic (late inactive)
What are the serum markers for Paget disease?
- elevated ALP
- normal Ca2+ and phosphorus
- urine hydroxyproline increased
