CBC 9/26 Flashcards
Components of CBC (5)
WBCs, RBCs, Hgb, Hematocrit (% of RBC in blood), platelets
Causes of erythrocytosis (4)
- Make up for small RBC size (thalassemia)
- Poor O2 carrying capacity of blood (secondary polycythemia)
- Autonomous RBC prod. (Primary polycythemia)
- Epo use (doping)
Normal adult Hgb levels in men & women?
Men: 13-17 g/dL
Women: 11.5-15.5
Typical cause of primary elevated Hbg?
Polycythemia Vera (myeloproliferative neoplasm)
Rarely familial
Typical secondary cause of elevated Hbg?
Hypoxia (ex. From copd)
Abnormal EPO production (tumors)
What is MCV?
Mean cell volume - avg volume of patents RBCs.
What is MCH?
Mean corpuscular Hbg - measure of Hbg content.
RBC
What is MCHC?
Mean corpuscular Hbg concentration - avg Hbg concentration per cell.
(Hgb x 100)/hematocrit%
What does low MCHC mean?
Anemia w/ decrease in Hgb compared to RBC size (iron deficiency)
What does high MCHC mean?
Disproportionate quantity of Hgb in RBCs - indicates presence of SPHEROCYTES in blood (RBC agglutination)
What is anisocytosis?
Variation in RBC SIZE - measured w/ RDW.
Microcytic anemia has ⬆ ️RDW, meaning ⬇️ iron.
What is poikilocytosis?
Variability in RBC SHAPE
What is a Schistocyte?
How are they formed?
RBC fragment from intravascular hemolysis.
Formed from bisection of discocyte by a FIBRIN thread. Then, schistocytes become spherical and hemolyze.
What is an acanthocyte?
RBC with spiked/thorny projections on plasma membrane.
Associated w chronic liver disease
What is a teardrop cell (dacrocyre)?
Tear drop shaped RBC, caused by myelophthisic disease (bone marrow infiltration)