hormones and growth - lecture

Question 1

GH effect in adults

Answer 1

metabolism: increases - so deficiency results in decreased lean body mass, muscle bulk, protein anabolism, lipolysis
deficiency => impaired glucose tolerance
muscle strength and growth

Question 2

causes of abnormal or stunted growth

Answer 2

deficiency of GH
laron dwarfism and african pigmyism - problems with receptors so don’t respond to GH
hypothyroidism - thyroid hormones needed for actions of GH

Question 3

placental lactogen

Answer 3

has 85% of structure but only 1% activity of GH

Question 4

GHBPs

Answer 4

might serve to dampen oscillations in serum GH secretion associated with pulsatile GH secretion

Question 5

hypoclycemia in GH

Answer 5

initially causes release of factors but over long term is hyperglycemic

Question 6

GH secretagogue receptor

Answer 6

where opioid like peptaides stimulate GH secretion

Question 7

grehlin

Answer 7

hunger inducing polypeptide

GH releasing peptide

Question 8

somatomedins

Answer 8

negative feedback at pituitary level on GH release

increase through adulthood - spike at puberty - drop off again in adulthood

Question 9

free FA

Answer 9

negative feedback at pituitary level on GH release