Antiarrhythmics

Question 1

class 1 drugs

Answer 1

sodium channel blockers

Question 2

class 1a drugs

Answer 2

moderate reduction in phase 0, increase APD, increase ERP

also blocks K

quinidine, procainamide, disopyramide

Question 3

class 1b drugs

Answer 3

small reduction in phase 0, reduce APD, decrease ERP

blocks inward slow NA current

lidocaine, mexilitine

Question 4

class 1c drugs

Answer 4

pronounced reduction in phase 0 slope, no effect on APD or ERP

flecanide, propafernone

Question 5

class 2 drugs

Answer 5

beta blockers- reduce rate and conduction

Question 6

class 3 drugs

Answer 6

potassium blockade- delays repolarization, increasing ERP and APD

sotalol, dofetilide, amiodarone, dronedarone

Question 7

class 4 drugs

Answer 7

block L-type Ca channels, most effective at SA and AV nodes, reduce rate and conduction

diltiazem, verapamil,

Question 8

adenosine

Answer 8

type 4 technically

prolongs AV conduction via hyperpolarization (increasing outward K) and stops catecholamine stimulation of ical and if