Osteoarthritis Flashcards
1
Q
Basic OA Information
A
MC type of joint disease
Erosion of Articular Cartilage
Intrinsic Disease of Cartilage - Not Inflamatory
2
Q
Secondary OA
A
Younger Individuals
- Injury to Joint
- Congenital Deformity
- Diabetes, Hemochromotosis, Obesity
3
Q
Pathogenisis of OA
A
Multifactorial
- Genetic (prostaglandin metabolism, WNT)
- Environment (aging, stress, obesity, strength)
4
Q
Pathogenisis of OA - chondrocyte involvement
A
- chondrocyte injury
- secrete inflammatory mediators
- drop out
5
Q
Morphology - Early OA
A
- Chondrocytes Proliferate
- Proteoglycans Decrease
- Type II collagen molecules degraded
6
Q
Morphology - Later OA
A
- Chondrocytes Die
- Full thickness sloughing of cartilage
- Joint Mice - peices of broken cartilage
- Bone Eburnation - polished ivory, friction
- Synovium MILDLY congested and fibrotic
7
Q
Clinical Course of OA
A
- Worsens with use
- Morning Stiffness
- Limited ROM, crepitus
- One or few joints
8
Q
Clinical Course of OA - Joints Affected
A
Hips, Knees, Lumber, Cervical, PIP, DIP
9
Q
Heberden Nodes - OA
A
Prominent Osteophytes at DIP
Women NOT men
