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MED1022 > All Drugs > Flashcards

All Drugs Flashcards

1
Q

Lignocaine

A

Amide LA

Widely used long half life

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2
Q

Bupivacaine

A

Amide LA
Long half life
Epidural

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3
Q

Amethocaine

A

Ester amide

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4
Q

Aspirin

A

NSAID
Non-selective
Irreversible inhibition of COX, good anti-platelet
Contra in asthma, bronchospasms from leukotrienes
Gastric bleeding

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5
Q

Ibuprofen

A

NSAID

Non-selective COX

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6
Q

Paracetamol

A

NSAID

Selective COX-2

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7
Q

Meloxicam

A

NSAID

COX-2

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8
Q

Methotrexate

A

DMARD
Folate agonist
Anti-cancer, inflammation, immunosuppressant
B/T cells

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9
Q

Azathioprine

A

DMARD

Purine analog

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10
Q

Leflunomide

A

DMARD

Pyrimidine analog

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11
Q

Mycophenolate

A

DMARD
Purine analog
T cell selective

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12
Q

Cyclosporin

A

DMARD

Calcineurin inhibitor, decrease IL-2, decrease T cells

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13
Q

Infliximab/Rituzimab

A

DMARD

Biologicals, used when other DMARDs don’t work

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14
Q

Allopurinol

A

DMARD used in gout

Inhibits production of uric acid, non-competitive inhibitor

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15
Q

Colchicine

A

DMARD used in gout

Inhibits migration of leukocytes into the joint

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16
Q

Probenecid

A

DMARD used in gout

Increases uric acid excretion

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17
Q

Morphine

A

Opioid
High affinity to mu receptors
Inhibits pain transmission to dorsal horn, activates descending inhibitory pathway, inhibits nociceptive fibers

18
Q

Codeine

A

Opioid
10-20% potency of morphine, weak mu agonist, metabolised into morphine
Lower doses for cough suppression

19
Q

Pethidine

A

Opioid
Morphine analogue, higher affinity to mu than codeine
Used in childbirth

20
Q

Tramadol

A

Opioid
Opioid agonist (weak mu) AND serotonin and noradrenaline reuptake inhibitor
Chronic neuropathic pain

21
Q

Naloxone/Naltrexone

A

Opioid
Competitive antagonist – no analgesic effects. Has affinity for all three receptors
Rapid reversal of opioid effect, used primarily to treat overdose

22
Q

Prednisolone

A

SAID

Needs to be converted by liver first

23
Q

Dexamethasone

A

SAID

More potent than Prednisolone

24
Q

Pyridostigmine/Neostigmine

A

ANS drug
Anti-cholinesterase
Used in Myasthenia Gravis

25
Q

Rocuronium

A

ANS drug
Non-depolarising blocker, competitive antagonist
Can be overcome be increasing [ACh]

26
Q

Suxamethonium

A

ANS drug

Depolarising blocker, nicotinic agonist

27
Q

Atropine

A

ANS drug

Competitive reversible antagonist of mACh receptors

28
Q

Perindopril

A

ACE inhibitor
Prevents conversion of angiotensin II
Causes cough

29
Q

Irbesartan

A

ARB (Angiotensin receptor blocker)

Doesn’t block bradykinin breakdown, no cough

30
Q

Atenolol

A

Beta Blocker

Cardio selective, only acts on B1 receptors

31
Q

Verapamil

A 
Calcium Channel Blocker
Centrally acting (SA and AV), thus no reflexive tachycardia
32
Q

Amlodipine

A

Calcium Channel Blocker

Peripherally acting, causes rapid drop in BP causing compensatory tachycardia and CO

33
Q

Hydrochlorothiazide

A

Diuretic - Thiazide

Inhibits NaCl reabsorption at distal tubule of nephron

34
Q

Frusemide

A

Diuretic - Loop diuretic

Inhibits NaCl reabsorption at ascending limb of loop of henle

35
Q

Spironolactone

A

Diuretic - Potassium sparing diuretic

Competetive aldosterone antagonists at collecting ducts of nephron.

36
Q

Digoxin

A

Positive Inotrope
Inhibit Na/K ATPase, increase Ca in myocardiocytes, increase contractibility, decrease conduction
Slows AV node conduction, potential bradycardia and AV block

37
Q

Glyceryl Trinitrate

A

Nitrate
Converted to NO
Vasodilators, reduces ventricular wall tension and myocardial oxygen demand

38
Q

Adenosine

A

Adenosine
Hyperpolarises cardiac conducting tissue
Slows pacemaker activity through alpha 1 at AV

39
Q

Atorvastatin

A

Lipid-lowering - Statin
Inhibits cholesterol synthesis
Increase LDL receptors, increase in HDL

40
Q

Gemfibrozil

A

Lipid-lowering - Fibrate
Stimulate lipoprotein lipase hydrolyse TAGs
Increase LDL receptors and HDL

MED1022 (2 decks)

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