Gallbladder - Physiology Flashcards
normal bile production
500 to 1000ml per day
bile production
vagal stim - increase/decrease?
splanchnic stim - increase /dec?
vagal increase
splanchnic dec
released in duodenum with presence of hypochloric acid and fatty acids
secretin
effect inc bile production
bile composition
water electrolytes bile salts proteins lipids bile pigments
ph of hepatic bile
neutral or slightly alkaline
high protein diet - acidic
primary bile salts
cholate and chenodeoxycholate
fmr cholesterol
conjugates bile salts
taurine and glycine
acts as anions balanced by sodium
89 percent of conjugated bile acids absorbed in
terminal ileum
20 percent conjugated bile acids deonjugated by gut bacteria to secondary bile acids namely
deoxycholate
lithocholate
secon bile acids absrobed in
colon
how many percent of bile os excreted in stool
5
principal lipids found in bile
cholesterol and phospholipids
responsible for bile color
bilirubin diglucuronide
concentration bile versus plasma (100x)
has the greatest absroptive power per unit area of any structure in the body
gallbladder mucosa
role in maintaining relatively low intraluminal pressure in the biliary tree
gradual relaxation and emptying of gallbladder
