Microbiology- Parasitic Infections

Question 1

What disease does typanosoma cruzi cause?

Answer 1

Chagas disease

Question 2

Chagas disease- epidemiology

Answer 2

central and south america, zoonosis

Question 3

Chagas disease- pathogenesis

Answer 3

blood sucking reduvid bugs –> defecate in wounds –> proliferation in cells –> dispersed around body

Question 4

Chagas disease- affected tissues

Answer 4

CNS, GI, and cardiac muscle

Question 5

Chagas disease- Sx

Answer 5

asymptomatic initally, chronic tissue destruction and myocarditis

Question 6

Taenia Solium (pork tapeworm)- epidemiology

Answer 6

south and central america and asia

Question 7

Taenia Solium- transmission

Answer 7

eating uncooked pork/bear which contains larvae

Question 8

Taenia Solium- pathogenesis

Answer 8

larvae in GI –> mature into tapework –> eggs hatch in adult GI –> can invade muscle or CNS

Question 9

Taenia Solium- Sx

Answer 9

asymptomatic

Question 10

Trichinella spiralis- morphology

Answer 10

nematode that can infect any animal and has a life cycle complete in 1 host

Question 11

Trichinella spiralis- transmission

Answer 11

infected pig meat

Question 12

Trichinella spiralis- pathogenesis

Answer 12

larvae digested out in GI –> adult works in mucosa –> eggs into blood –> larvae penetrate SM and mature

Question 13

Trichinella spiralis- Sx

Answer 13

light infections are asymptomatic, inflammatory rxns. Fever, muscle pain weakness and eosinophilia in heavy infections

Question 14

What is an amastigote?

Answer 14

A cell that doesnt have visible flagella or cilia

Question 15

What is a trypmastigote?

Answer 15

a kinetoplast is near the posterior end of the body and the flagellum lies attacked to the cell body for most of its length

Question 16

What is the trypomastigote life cycle?

Answer 16

tiatomine take blood meal –> penetrates varios cells –> multiple by binary fission in tissues –> amastigotes mature into trypomastigotes and then enter blood –> tiatomine –> epimastigotes in midgut –> multiply in midgut –> move to hindgut

Question 17

What are the 2 drugs to treat Chagas?

Answer 17

Benznidazole or Nifurtimox

Question 18

What are cysticeri?

Answer 18

muscle infection caused by the ingestion of T. solium eggs that hatch and the larve invade muscle and the CNS

Question 19

What diagnostic tool can you use to Dx cysterceri?

Answer 19

Cysticeri in muscle eventually calcified and can be seen on radiograph

Question 20

What is the drug of choice for trichinellosis?

Answer 20

Albendazole