Physics Flashcards

1
Q

Equation for maximum number of electrons for each shell.

A

2n^2
K=2(1)^2=2
L=8
M=18

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Number of substrates for each shell.

A

2n-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

A: atomic mass

A

P+N

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Z

A

Number of protons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

N

A

Number of neutrons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Isotopes

A

Same number of protons, Z

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Isotopes

A

Same number of neutrons,N

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Isobars

A

Same number of atomic mass, A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Line of stability

A

Low z number –>p:n is 1:1
High z number –> p:n is 1:1.5
Radioactive element seeks stability, this transition is called mode of decay

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Modes of decay

A
b- decay
b+ decay
Electron capture
Isomeric transition/internal conversion
Alpha decay
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

b- decay

A

n –> p + e- + v + energy

V =neutrino, behaves like a particle with no mass and is not critical to imaging consideration

Daughter has an extra proton
Z+1 and N-1
Atomic mass same

B- particle is of no use in imaging and may contribute to increase radiation dose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

b+ decay

A

P –> n + e+ + v + energy

b+ particle (positively charged electron) will be attracted to and collide with a free negatively charged electron –> annihilation of both particles –> conversion of mass to energy state, E=mc2

Annihilation produce 2 photons, 511 keV, emitted 180 degree from each other. This is what is registered into an image in positron imaging, PET

Z-1
N+1
Atomic mass same

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Electron capture

A

P + e- –> n + v + energy

Vacancy left by captured electron would be filled by an outer shell electron and lead to cascade of an electron to fill vacancy, will lead to emission of characteristic X-ray and Auger electrons

201Tl - characteristic X-rays that are imaged

Z-1
N+1
Atomic mass same

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Isometric transitions and internal conversions

A

Excited state/metastable state exist for very short periods, less than 10^-12 sec, but may exist for hours, this lead to release of energy in form of radiation without changing p to n ratio. This is called isometric transition and results in electromagnetic emissions called gamma rays; same as X-rays but differ from origin, which is from nucleus

There is also a competing process called internal conversion

Ex. 99mTc –> 99Tc; isometric transition is 87% and rest are internal conversion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Alpha decay

A

Occur in unstable nuclei with high atomic masses

Alpha particle consists of 2 protons and 2 neutrons, helium nucleus; travels shirt distance given high charge and heavy mass.

No application in imaging

Z-2
N-2
A-4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

B- decay of 99Mo yields 99Tc, which then decays to 99mTc by isometric transition/internal conversion

Sample of 99Mo will always have same proportion of 99mTc and 99Tc.

Since both parents are decaying, would reach equilibrium based on half lives.

This is employed by both technetium and rubidium generators

A

Parent-daughter equilibrium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Transient equilibrium

A

When parent half-life is marginally longer than daughter, amount of daughter in mixture will reach a maximum over a period of time.

Elapsed time will be multiple if half lives if daughter.

Equilibrium is reached after relatively few daughter half lives have passed

Basis of 99Mo-99mTc generators; four 99mTc half lives

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Secular equilibrium

A

Half life of parent is markedly longer than that of daughter.

Since parent is decreasing so slowly relative to daughter, mixture appears to have half life of parent

Basis of 82Sr-82Rb generators used in PET imaging
82Sr 25 days
82Rb 1.2 min.

Many half lives of daughter must pass before equilibrium is reached

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Number of decays for a given time equation

A

N(t) = N(0) e^-decay constant x time

N(t) is number of unstable nuclei remaining after elapsed time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Decay factor

A

e^-(decay constant x t)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Half life and decay constant relationship

A

T1/2= 0.693/decay constant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Unit of activity, A

A

Same equation as nuclear decay

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Particles interactions with matter

A

Alpha or beta particles interact with matter through collisions, resulting in excitation, ionization, or bremsstrahlung.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Excitation

A

Low energy, electron is energized but does not exceed binding energy; increased energy is dissipated generally as heat radiation.

25
Q

Ionization

A

Higher energy interaction
Incident particle transfers enough energy to exceed binding energy of electron; ion pair formed, an energized free electron and a positive ion.

26
Q

Bremsstrahlung

A

High energy interaction
More typical of high energy particles interacting with high Z number matter
Incident particle penetrates the electron cloud and interacts with charged field of the nucleus and trajectory of incident particle is markedly changed, resulting in decreased in velocity, energy loss produced photons of X-rays called bremsstrahlung (German for “breaking radiation”)

27
Q

LET

A

Linear energy transfer

Alpha particle has high let (high charge and heavy mass)
Beta low let (little charge and low mass)

28
Q

Photon interactions with matter

A

Photoelectric absorption
Compton scatter
Pair production

29
Q

Photoelectric absorption

A

Photo transfers all of its energy to an inner shell electron

Photon is completely absorbed and electron, called a photoelectron is ejected

Energy of photoelectron is equal to photon energy less its binding energy. Energy of photon converted from electromagnetic energy to kinetic energy.

Vacancy left by the ejected electron is quickly filled by an outer shell electron; characteristic X-rays and auger electrons are then emitted.

30
Q

Compton scatter

A

Photon interacts with an outer shell electron; photon is not completely absorbed, unlike photoelectric absorption.

Transfers a portion of its energy to the electron, called Compton electron, which is subsequently ejected.

Most probable interaction in imaging of 201Tl (Hg X-rays) and 99mTc gamma rays in tissues.

Source of image degradation, but can be identified by their lower energy values.

31
Q

Pair production

A

High energy photons may completely avoid interacting with orbital electrons and interact in the magnetic field of the nucleus. Resulting in creation of a pair of election, one positive and one negative. Positive one combines with a negative electron, creating two 511 kEV photon; energy of the incident photon must be at least two times the mass energy equivalency of an electron (511 keV) or 1.022 MeV. Energy in this range are not used for imaging.

32
Q

Attentuation

A

Affected by thickness of absorber, along with photon energy and atomic number.

Thickness of absorber increases, fraction of transmitted photon will decrease.

Linear attentuation coefficient, my

I(x) = I(0)e^-mux

If thickness reduces beam intensity by 50%, imaging effect would be a reduction in count density of 50% as well.

33
Q

Half value thickness

A

HVT =0.693/mu

34
Q

201Tl HVT in tissue(h2o)

A

38mm

35
Q

99mTc HVT

A

46mm

36
Q

82Rb HVT

A

73mm

37
Q

1 gray (Gy)

A

Absorbed dose equal to 1 J of radiation energy absorbed by 1 kg of matter (1J/kg)

38
Q

1 rad

A

Dose of radiation that imparts 100 erg to 1 g of matter.

39
Q

Conversion of gray to Rad

A

1 gray = 100 rad

40
Q

Roentgen (R)

A

Amount of electric charge produced by radiation in a unit mass of air

1 rad ~ 1.07 R

Exposure rates common to nuclear medicine range from 0.1 to 10 mR/h.

41
Q

Survey meter

A

Gas radiation detector I

42
Q

Film dosimeters

A

Radiation interacts with photographic film and resulting film exposure can be used quantitatively to estimate dose

43
Q

TLDs

A

Radiation induction of defects in crystals.

On heating, gives off light proportional to the absorbed dose.

44
Q

Stochastic effects

A

Induction of genetic mutations in offspring and the induction of malignant rumors

All or nothing

With increasing dose, probability of a stochastic effect increases

45
Q

Non-stochastic effect (deterministic)

A

Do not occur below a certain dose

E.g. Lymphopenia, azoospermia, erythema, epilation, pancytopenia, cataract
Encountered from 25 rad to 200 rad

At higher dosages, systemic manifestations occur, acute radiation poisoning; fatigue, nausea, vomiting

At very high dose, death

Less common

46
Q

Sv to Rem conversion

A

1Sv =100 mrem

47
Q

201Tl Cl critical organ

A

Testes/kidneys

48
Q

99mTc sestamibi critical organ

A

Upper large intestine

49
Q

99m Tc tetrofosmin critical organ

A

Upper large intestine

50
Q

99m Tc-labeled RBCs critical organs

A

Spleen

51
Q

82Rb chloride critical organ

A

Kidneys

52
Q

18FDG critical organ

A

Urinary bladder wall

53
Q

Radiation protection methods

A

Distance
Shielding
Time

54
Q

Occupational exposure of adult radiation workers

A

5 rem, 0.05 Sv effective dose

50 R.E.M., 0.5 Sv dose equivalent to any organ other than lens of eyes in 1 year

55
Q

Natural resources public average exposure

A

0.3 rem/year

Higher altitude, Denver Colorado, 1 rem/year

56
Q

Limit dose for public

A

Less than 0.1 rem (1mSv) per year

57
Q

ALARA

A

As low as reasonably achievable

58
Q

Patients injected with 99mTc will emit detectable levels of radiation for?

A

24-48 hrs

59
Q

Patients injected with 201Tl will emit detectable levels of radiation for?

A

2-4 weeks