Intro to Cell Signaling and Pharmacology to Receptors Flashcards
The cytokine receptor is a receptor-associated example of a tyrosine kinase receptor. Which of the following families of receptors does the cytokine receptor fall into?
A. Ligand-gated ion channel
B. Transcription factor
C. Guanylyl cyclase
D. Receptors as enzymes
E. G-protein coupled receptor
D
Some receptor subtypes or isoforms within a given class can couple to different downstream effectors. Which is an example of this feature?
A. D1 and D2 dopamine receptors that are not particularly selective for endogenous ligands
B. Muscarinic AChRs are G-protein coupled, nicotinic AChRs are ligand-gated
C. Distinct subtypes of AChRs exist in brain versus muscle
D. M1 and M3 AChRs couple to a G-protein called Gq, while M2 and M4 AChRs couple to Gi
D
The receptor for atrial natriuretic peptide is what type of enzyme receptor?
A. Tyrosine kinase
B. Guanylyl Cyclase
C. Serine/Threonine kinase
D. Protein tyrosine phosphatase
B
The following graph is an example of what deviation from classical receptor behavior?
A. Cooperativity
B. Spare receptor
C. Partial agonist
D. Competitive antagonist
E. Noncompetitive antagonist
B - spare receptors lead to a left shift in the dose response curve
Which of the following is an effect of spare receptors?
A. EC50 decreases
B. Kd increases
C. Kd decreases
D. EC50 increases
A - the EC50 decreases because the half-maximal response is attained at [L] < the Kd
Which of the following drugs acts as a partial agonist?
A. Haloperidol
B. Benzodiapines
C. Aripiprazole
D. Propananol
C - Aripiprazole is a partial agonist of the D2 receptor and acts to improve some symptoms of schizophrenia.
Which of the following drugs acts as an inverse agonist?
A. Haloperidol
B. Benzodiapines
C. Aripiprazole
D. Propananol
D - propananol blocks downstream effectors that trigger cAMP production but activate other effectors coupled to the B2 adrenergic receptor.
