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Flashcards in Biochem Deck (9)
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1
Q

Define hydrophilic in terms of bonds

A

Hydrophilic molecules have polar covalent bonds - e.g. That one of the atoms is more electronegative than the other (significantly higher affinity for electrons). More polar bonds at one end of the molecule makes it more hydrophillic- i.e. Polar bonds that are symmetrical the molecule is less hydrophillic.

2
Q

Name 3 common bonds that are polar

A

C-O
C-N
O-H
Also ionic compounds with + or - charge

3
Q

Bilayers are formed by _________ molecules because __________

A

Amphipathic, phillic ends attracted to cytoplasm, phobic ends repel.

4
Q

If you know the conc of H+ ions what equation finds the pH?

A

pH = -log [H+]

5
Q

If you know the pH what equation finds the conc of H+ ions?

A

10^-pH = [H+]

6
Q

For a ________ decrease in pH the H+ conc is ____________

A

0.3, double

7
Q

How does the bicarbonate buffering system work? (Equation & Enzyme). What happens to the equilibrium when you add/remove H+ ions?

A

CO2 + H20 -> H2CO3 -> HCO3- + H+

Carbonic anhydrase catalysts the first bit

Add H+ = shifts to left, Remove H+ = shifts to right

8
Q

What is the Henderson Hasslebach equation and what can it be used to work out?

A

pH = pKa + log [base
acid]

Can be used to find out pH, pKa, base:acid ratio, base/acid concentration

9
Q

What effect does hyperventilation and pulmonary obstruction have on pH?

A

Increase as more CO2 is expelled so less carbonic acid made.

Pulmonary obstruction would decrease pH as CO2 retained due to problem getting air out.