Lecture 9.5 - Progesterone

Question 1

progesterone:
effect on endometrium?
causes a \_\_\_\_ in body temp;
increases \_\_\_\_ sensitivity;
causes a decrease in \_\_\_\_ reabsorption by competing with \_\_\_\_

Answer 1

increased secretions, spiral artery development;
increase;
insulin;
Na;
aldosterone

Question 2

progestins are used for ____, ____ cancer, abnormal uterine ____

Answer 2

contraception, endometrial;

bleeding

Question 3

progestins:
17 ethynyl group ____ oral bioavailability;
replacement of 19-methyl with H _____ activity

example of this is _____

Answer 3

increases;
increases;

norethindrone

Question 4

_____ is a 2nd gen progestin. has higher oral bioavailability

Answer 4

levonorgestrel

Question 5

____ is a 3rd gen progestin. a prodrug for etonogestrel which has high oral bioavailability

Answer 5

desogestrel

Question 6

progestins often have ____ and ____ effects in addition to progesterone effects

Answer 6

androgen, anti-estrogen

Question 7

hormonal contraceptives (OCPs) are typically combinations of progestins and ____. they inhibit _____ and prevent the estrogen surge. this prevents _____

Answer 7

ethinyl estradiol;
LH/FSH;
ovulation

Question 8

OCPs:
cause ____ of cervical mucus.
cause ____ of the breast.

Answer 8

thickening;

enlargement

Question 9

OCP side effects:
contradindicated in smokers greater than 35 years old due to risk of _____;
______;
___ cancer

Answer 9

cardiovascular events (ie MI);
thromboembolism;
breast

Question 10

post-coital contraceptives (morning after pills):
differ from regular OCPs in that they are ____;
side effects such as ___ and ____ are more common

Answer 10

at much higher doses;

nausea, vomiting

Question 11

_____ (RU-486) and _____ are progesteron antagonists. used as _____

Answer 11

mifepristone, ulipristal;

emergency contraceptrives

Question 12

mifepristone is used in combination with _____, which is a ____ analog;
most severe side effect is _____

Answer 12

misoprostol, PGE1 analog;

bleeding

Question 13

danazol acts as a _____ at androgen receptors;
used to treat _____ and hereditary angioedema;
associated with weight ____, acne, ______, ____ toxicity

Answer 13

partial agonist;
endometriosis;
gain, hirutism/masculinization;
liver