Parathyroid

Question 1

parathyroid = ___ cells supported by ___

Answer 1

chief

oxyphil

Question 2

chief cells in PT gland function and appearance

Answer 2

secrete PTH

round cells with bland central round nuclei

Question 3

oxyphil cells in PT gland histological appearance

Answer 3

slightly larger than chief cells with acidophilic cytoplasm

Question 4

causes of hyperPT (3)

85-95% =

Answer 4

hyperplasia
adenoma - 85-95%
carcinoma

Question 5

5-10% of PT hyperplasia is associated with

Answer 5

MEN 1 and 2a

Question 6

in hyperPT this cause involves one gland and causes the others to atrophy =

Answer 6

adenoma

Question 7

this cause of hyperPT usually involves all 4 glands

Answer 7

hyperplasia

Question 8

2ndry hyperPT =

causes eg.s

Answer 8

chronic hypocalcaemia causes overactivity and hyperplasia

low Ca2+/vitD intake, renal failure

Question 9

tertiary hyperPT =

associated with ___

Answer 9

autonomous

hypercalcaemia

Question 10

hypercalcaemia s+S

Answer 10

bone (pain, #, osteoporosis, osteitis fibrosa cystica)
renal stones
constipation
depression
lethargy

Question 11

DiGeorge and thyroid Sx are two causes of

Answer 11

hypoPT

Question 12

familial hypoPT is associated with

Answer 12

primary adrenal insufficiency and mucocutaneous candidiasis -AI

Question 13

s+S of hypoPT

Answer 13

tetany (Chvostek’s and Trousseau’s sign), psychosis, anxiety, Parkinsonism, papilloedema, lens calcification and cataracts, QT prolonged