Direct Renin Inhibitors

Question 1

What is the only drug in this class?

Answer 1

Aliskiren

Question 2

What does it treat?

Answer 2

HTN

Question 3

How does it work? (Hint: ACE, ARBs)

Answer 3

Stops activation of Angiotensin 1

Question 4

Inactivation of A1 causes? (3)

Answer 4

vasodilation, urinary excretion of Na and H2O and retain K (less A2 and aldosterone)

Question 5

What are S/E?

Answer 5

Angioedema, Hyperkalemia, Diarrhea (Tx of S/E similar to ACE/ARBs)

Question 6

Dose, Route, and Administration(Food)?

Answer 6

PO only, avoid taking with high fat foods

Question 7

What to report?

Answer 7

Hyperkalemia S/S, cough, angioedema, GI S/S