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Pharmaceutics > Tablets and excipients > Flashcards

Tablets and excipients Flashcards

1
Q

What is a Diluent?

A

inert substances added to increase the bulk weight of the tablet

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2
Q

What is the purpose of a diluent?

A

incrases ability to dispense if tablets are bigger

impossible to make a tablet with a small amount of drug only

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3
Q

What are examples of diluents?

A 
Clay-
Salts- 
Inert sugars- lactose mannitol sorbitol
Polysaccharides- 
Starch-
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4
Q

What are binders?

A

becomes sticky and gluey upon wetting

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5
Q

What is the purpose of binders?

A

used to ensure tablet stays together and improves free flowing qualities to desired hardness and size

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6
Q

What are examples of common binders?

A 
Inert sugars
polysaccharides
gums
gelatin
cellulose derivatives
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7
Q

What is the consiquence of too much binder?

A

makes tablet too hard and can not disintegrate

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8
Q

What is a lubricant?

A

water repelling materials

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9
Q

What is the purpose of a lubricant?

A

prevent adhesion of tablet to a surface by creating a barrier
improves flowability

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10
Q

What are examples of lubricants?

A

fatty acids
polyethylene glycols
Magnesium stearate
sodium lauryl sulfate

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11
Q

What is the purpose of glidant?

A

promote flow of the tablet granulation or powder materials

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12
Q

What are examples of glidants?

A

colloidal silicon dioxide

Talc

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13
Q

What is a glidant?

A

neg charged particles absorb on surface of granules to prevent interactions of granules

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14
Q

What is the purpose of disintegrant?

A

facilitate break up of tablet after administration

absorb water rapidly

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15
Q

What charactoristics contribute to rate of disintegration?

A

wettability and ability to swell

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16
Q

What are examples of disintegrants?

A

corn/potato starch
clays
polysaccharides

17
Q

What is the purpose of colors and dyes?

A

disguise off color of drug
provide product identification
produce more elegant product

18
Q

What problems can result from use of colors or dyes?

A

not photostable

19
Q

What is the purpose of flavoring agents/artificial sweetners?

A

make the tablet palateable

used in chewable and dissolving tablets

20
Q

What is the granulation process?

A

homogenous mixing of ingredients to improve flow and compressability

21
Q

What is the wet granulation process?

A

most widely used

binding agent added to mixed powders via stirring

22
Q

What are some cons to wet granulation?

A

timely and labor intensive

need to dry mixture- api can be moisture sensative

23
Q

When is the dry granulation process used?

A

used for api sensative to heat, when tablet has sufficient binding properties

24
Q

Why coat a tablet?

A

improves stability, masks odor/taste, easier to swallow, ID product, improve handling, modify drug release

25
Q

What are components of film coatings?

A

Polymer, plasticizers, colorants, solvents

Pharmaceutics (2 decks)

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