Potassium Sparing Diuretics Flashcards
1
Q
Example
A
Amiloride
2
Q
Indications
A
Adjunct to diuretic use in hypertension or heart failure (SPECIALIST USE)
3
Q
What are the contraindications of PSDs?
A
- Hyperkalaemia
- Anuria
- Addisons
4
Q
Cautions
A
- Diabetes mellitus
- Renal impairment
- Pregnancy and breast feeding
5
Q
What channels does amiloride block and where are they found?
A
- Sodium channels
- Distal tubule
- Reduction is sodium reabsorption leads to reduction in water reabsorption
6
Q
How is pH maintained when using amiloride?
A
- Potassium also lost
7
Q
How is amiloride administered?
A
- Oral
8
Q
Adverse reactions to amiloride?
A
- Hyperkalaemia
- Hyponatraemia
- GI upset
9
Q
What drugs does amiloride interact with?
A
Drugs that increase potassium levels
- ACE-I
- Angiotensin II antagonists
- Aldosterone antagonists
These will increase the hyperkalaemia (may also occur with NSAIDs)
