Steatosis Flashcards
1
Q
Aetiologies?
A
ALCOHOLISM
Metabolic syndromes
Obesity
Malnutrition/starvation
2
Q
Pathology?
A
Ethanaol/other –> increased mitcochondrial oxidation of fatty acids, increased synths and delivery of FA and decreased removal from hepatocytes –> accumulation of fat intracellularly
REVERSIBLE
3
Q
Signs and Symptoms?
A
Late hepatomegaly most common
Signs of portal hypertension
4
Q
investigations and findings?
A
FBC
LFT - Increased AST & ALT, ALT:AST ratio > 1 in alcohol related
Lipid profile - hyperlipidaemia
USS - fatty liver visualised
5
Q
Management?
A
Abstinence of alcohol/relieving cause will reverse liver damage
6
Q
Complications?
A
Steatohepatitis
Cirrhosis
