Lecture 18 - PTSD Flashcards

1
Q

What category in DSM-III; DSM-5?

A
  • III: anxiety

- 5: trauma & stress related

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2
Q

Criteria in DSM-5

A
A - exposure to actual or threatened death, serious injury/violence or threat to self or others through direct experience, witnessing or learning
B - Intrusive Symptoms
C – Avoidance 
D – Mood/Cognitive alteration 
E - Increased arousal and reactivity 
F -  at least 2 months
G - causes functional impairment
  • Often have remission after 3 months; if remission after 6 months = chronic
  • Delayed onset PTSD: ~5% of cases
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3
Q

Prevalence

A

between 3-8%
But lifetime trauma exposure is 75% !
PTSD symptoms are normal following trauma exposure; but usually don’t meet criteria for PTSD

Women:Men –> 2:1
Common comorbidity: anxiety, substance abuse, depression

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4
Q

Leading Causes of PTSD

A
o War 
o Sexual assault 
o Violent crime 
o Motor vehicle accident 
o Childhood abuse
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5
Q

Risk factors

A

o Interpersonal vs. non-interpersonal stressors (interpersonal more; stressors that occur when other people are involved…ex: divorce)
o Severity of trauma (ex: amount of combat exposure)
o Female
o Family history of psychopathology, parental PTSD
o Personal psychopathology (already have another issue)
o Lower IQ (for combat-related PTSD)
o Childhood abuse
o Poor social support

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6
Q

Behavioural Treatment

A

o Prolonged Imaginative Exposure:

  • Breathing retraining & relaxation training
  • Repeated exposure to the traumatic memory (ex: go with client in detail through the situation)
  • Repeated in vivo exposure to situations avoided because of trauma-related fear (not always possible, but if they have PTSD from a car accident can slowly get them into a car)
  • *BUT, very hard (50% attrition rate)
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7
Q

Cognitive Processing Therapy

A

Aims to fix:

Two types of cognitive-distortions (self, or related to the world)
1) The sufferer is incompetent
• Others would have prevented the trauma
• Other who are not weak would not experience PTSD symptoms
2) The world is dangerous

Individuals with chronic PTSD reported more self-blame and negative thoughts about the self and the world than traumatized individuals without PTSD

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8
Q

Appraisal of the Sequelae of the Trauma

A

Appraisal:

  • Initial PTSD symptoms
  • People’s reaction in the aftermath of the trauma
  • Consequences of the trauma on other life domains
    • Produce negative emotions
    • lead to dysfunctional coping (avoidance and numbing)
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9
Q

Cognitive therapy

A

o Script, Impact statement

o Identify dysfunctional thoughts, beliefs and behaviours

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10
Q

EMDR; Eye Movement Desensitization and Reprocessing

A
  • While performing saccadic movement of the eyes:
    • Accessing traumatic images and memories, generating alternative cognitive appraisals of these images and memories
      -Meta-analysis
    • No more effective than other exposure therapy
    • Eye movement not essential for the therapeutic effect
  • But, some positive studies recently published
    Still controversial**
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11
Q

Effective treatments

A

o Prolonged exposure
o Cognitive processing therapy
o Combination of these
o Effective but difficult

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12
Q

Pharmacotherapy

A

SSRIs, MAO inhibitors, Neuroleptics (ex: valproate), propranolol

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13
Q

Effect of Mindfulness Therapy

A

STUDY: take veterans with PTSD and gave them mindfulness techniques
Results: there was a greater decrease in symptoms for the participants given mindfulness techniques compared to those given present-centered group therapy; but moderate effect size
** One of the strategies that can be used as an extra tool to diminish symptoms is mindfulness**

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14
Q

Biological mechanism

A

o Hippocampus (smaller in PTSD people; twin study; both twins had smaller hippocampus, but twin who went to war had PTSD)
o Amygdala
o Prefrontal cortex

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15
Q

STUDY: Imaging during Trauma Recall

A
Increased blood flow: 
 • Posterior cingulate 
 • Anterior prefrontal cortex, motor cortex
Decreased blood flow:
 • Right hippocampus 
 • Visual association cortex 
 • Anterior cingulate
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16
Q

Fear Conditioning Model of PTSD

A

o Response to trauma (US) with arousal and fear (UR)
o Then show arousal (CR) when exposed to trauma-related cues (CS)
o Fear conditioning: physiological responses even when the threat is not processed consciously
o Key for amygdala in fear conditioning**
o Amygdala damage = no fear conditioning
o PTSD: increased amygdala activation**

17
Q

Extinction & PTSD

A

o Repeatedly presenting the CS without the US
o Medial PFC involved
- Animal: damage in mPFC interfere with extinction
- Human: size of mPFC related to extinction facility
o Prolonged stress lead to densritic hypotrophy in mPFC and hypertrophy in amygdala
o PTSD:
- Less activation in mPFC
- Negative correlation b/w mPFC and amygdala
o medial PFC/amygdala involved with extinction

18
Q

Propranolol

A

o Med to reduce bp
o Highly discussed in media as “memory eraser”
o Rodent/animal work: reduces noradrenergic activity, especially under stress
o Preliminary evidence that it impacts activation in amygdala-PFC circuit
o Studies in humans show that propranolol disrupts reconsolidation processes, or enhance extinction learning, thereby dampening fear responding
o More research still needed

19
Q

Altered HPA Axis Functioning

A
  • PTSD altered HPA-axis regulation
  • High CRH
  • Low cortisol (impairs memory)