Hepatic Viruses

Question 1

Is there a vaccine available for Hep B?

Answer 1

Yes

Question 2

What is the MOA of lamivudine in the treatment of Hep B?

Answer 2

Nucleoside analogue- inhibits reverse transcription

Question 3

Describe the HBV vaccine

Answer 3

HBsAg subunit vaccine - produced in yeast cells that form spherical aggregates of the hep B surface antigen

Question 4

Describe the Hep D genome

Answer 4

Circular RNA virus that encodes the delta antigen

Has ribozyme activity that cleaves and ligates RNA

Question 5

What class of drugs “cure” Hep C infections?

Answer 5

Direct acting antivirals

Question 6

Name the three new antivirals used against HCV

Answer 6

Protease inhibitors (NS3)
Phosphoprotein inhibitors (NS5A)
Polymerase inhibitors (NS5B)

Question 7

What population is most at risk for fulminant hepatitis following an infection with Hep E?

Answer 7

Pregnant women

Question 8

What is the vaccine available for Hep A?

Answer 8

Killed virus

Question 9

Which hepatitis strains may become chronic?

Answer 9

B/D and C

Question 10

Differentiate treatment of Hep B from Hep C

Answer 10

Hep B: reverse transcriptase inhibitors

Hep C: DAAs