exam 2 stuff other than cytokines Flashcards
lymphocyte populations
NK cells, T cells, B cells
What cells do lymphoid stem cells produce?
B cells- memory and plasma
T cells: Th1, Th2, Th17, Treg
NK cells
T cell properties
produced in thymus, also go to lymph node paracortex, spleen, periarterial sheath, higher circulating amount in blood than B cells, receptor is TCR (CD3, CD4, CD8), recognizes foreign proteins in MHC antigens, form effector T cells, memory T cells, secrete cytokines, induce tolerance
B cell properties
Bone marrow, bursa, Peyer’s patches, distributed in lymph node cortex and splenic follicles, BCR and immunoglobin (on surface), recognizes free foreign proteins, tolerance induction is difficult, forms plasma cells and memory cells, produce immunoglobins
Which CD is present on all T cells?
CD3
What type of T cell is CD4 located on?
Helper T cells, MHCII receptor
What type of T cell is CD8 located on?
cytotoxic T cells, MHC I receptor
B1 integrins (CD29/CD49)
fibronectin, laminin, collagen
B2 integrins (CD11/CD18)
ICAM-1
selectins in vascular endothelial cells
P,L,E
lymphocyte mitogens
PHA, concanavalin A, pokeweek, LPS, BCG
What are helper T cells stimulated by?
exogenous antigens presented on DC
What are the two types of TCR?
alpha/beta, gamma/delta
alpha/beta- CD4 and CD8
what can CD4 cells differentiate into
- helper 1,2, 17, regulatory
- memory
what do CD8 cells differentiate into
cytotoxic and memory T cells
What does CDR stand for?
complementary determining region
where is the CDR determining region located?
in the variable portion of the receptor
what type of complementary determining region is present on all T cells?
CD3
What is CD3 composed of?
5 protein chains: gamma, delta, epsilon, zeta, nu
protein dimers
function in signal transduction
Co stimulatory molecules you should know in case he decides to be a dick
CD40-CD154: on interleukins
CD28-CD80 on APC
CD28-CD86
CD152-CD80/86
What does CD28-CD86 do?
- causes 8-fold activation of B cells
- causes T cell activation
What does CD152-CD80/86 do?
T cell suppression
When DC1 produces high IL-12 what type of Th cell is activated?
Th1
When DC2 doesn’t produce IL-12 what type of Th cell is activated?
Th2
What is the effect of Th17 cells?
plays a role in humoral immune response and produces inflammation