Action potentials

Question 1

Sympathetic neurotransmitters?

Answer 1

Pre-ganglionic: ACh

Post-ganglionic: NA

Question 2

Parasympathetic neurotransmitters?

Answer 2

Pre- and post-ganglionic : ACh

Question 3

Sympathetic pre-ganglionic neurons synapse at…

Answer 3

the sympathetic chain / ganglia

Question 4

Parasympathetic pre-ganglionic neurons synapse…

Answer 4

in the target organs

Question 5

Mode of action of G-protein coupled receptors?

Answer 5

1. Binding of agonist to receptor
2. GDP dissociation from alpha subunit
3. GTP binds
4. Alpha subunit modified effector
5. GTP is hydrolysed
6. Alpha subunit moves back to beta/gamma subunits

Question 6

Types of GPCR Muscarininc ACh receptors?

Answer 6

M1 (stomach, increase acid secretion)

M2 (heart, decrease rate)

M3 (airway smooth muscles, induce contraction)

Question 7

Types of GPCR Adrenoceptors?

Answer 7

beta1 (heart, increases contraction rate and force)

beta2 (airways smooth muscle - relacation)

alpha1 (vascular smooth muscle, contraction)

alpha2