Assessing Family Histories Interactive

Question 1

What are the components of a targeted family history?

Answer 1

Age of onset, number of affected relatives, disease severity in affected individuals, and presence of related disorders.

Question 2

What is considered late onset Alzheimer’s disease (AD)? What is it the cause of?

Answer 2

> 65 years old, most common cause of dementia in this population

Question 3

What percentage of Alzheimer’s cases are familial?

Answer 3

25%

Question 4

What genetic testing from hereditary Alzheimer’s is available?

Answer 4

Autosomal dominant early onset familial alzheimer’s disease (EOFAD), testing for three alleles which are commonly implicated

Question 5

What susceptibility allele has been associated with increased risk for Alzheimer’s disease, but is not required?

Answer 5

APOE e4 allele