B8 L5 Flashcards
Growth Hormone release
from anterior pituitary in response to GHRH
inhibited by somatostatin
GH Effects
increase blood levels of glucose, lipids, aa (anti-insulin)
protein synthesis and organ growth
bone growth
makes somatomedins
Somatomedins
IGF- Insulin-like Growth Factors
increase utilization of energy sources for growth
Stim GH release
exercise and sleep
Inhibit GH release
obesity and old age
Congenital Growth Hormone Deficiency
failure to grow and develop normally in first months
give GH to catch up
Growth Hormone Deficiency in Children
short, possible future dwarfism
underdeveloped features, poor bone density, low muscle mass, late to puberty
Growth Hormone Deficiency in Adults
loss of mean muscle; obesity
poor bone density
increased risk of cardiovascular disease
Excess Growth Hormone
pituitary gigantism
VERY tall
early mortality
Acromegaly
GH excess after closure of growth plates, usually pituitary tumor
growth of all soft tissues and organs
cardiovascular issues
growth of fingers, nose, ears, but no height gain
insulin resistant
bitemporal hemianopia
Hormones stored in posterior pituitary
oxytocin
ADH
Oxytocin origin
hypothalamus- paraventricular nucleus
ADH origin
hypothalamus- supraoptic nucleus
ADH release
too high plasma Osm
too low blood vol
ADH Function
insert aquaporins in CD to reabsorb water (V2)
vasoconstrictor (V1)
