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Antibiotics > Dihydrofolate Reductase Inhibitors > Flashcards

Dihydrofolate Reductase Inhibitors Flashcards

1
Q

Example

A

Trimethoprim

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2
Q

MoA

A

Bacterial dihydrofolate reductase
Antagonist
Inhibits reduction of dihydrofolic acid to tetrahydrofolic acid
Prevents bacterial DNA synthesis

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3
Q

Indications

A

Simple UTIs

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4
Q

ADR

A

GI, Rashes, Anaemia
Hyperkalaemia
Hypersensitivity
Decreased haematopoiesis

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5
Q

Prescribing Advice

A

Combine with Sulfamethoxazole = Co-trimoxazole for P carinii, Toxoplasmosis, Nocardiasis
X Pregnancy, Blood dyscrasia

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Antibiotics (13 decks)

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