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CV therapeutics > Statins > Flashcards

Statins Flashcards

1
Q

Give some examples

A

Simvastatin

Atorvastatin

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2
Q

What are the indications for use

A
  • 1o prevention CVD (>40yrs)
  • 2o prevention CVD
  • 1o hyperlipidaemia
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3
Q

What are the mechanisms of action

A
  • Reduce serum cholesterol evels
  • Inhibit HMG CoA reductase enzyme involved in making cholesterol
  • Decrease cholesterol production by liver & inc clearance of LDL from blood
    Also indirectly reduce triglycerides & slightly inc HDL levels.
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4
Q

What are the side effects

A
  • Headache
  • GI disturbance
  • serious effects on muscles (myopathy, aches, rhabdomyolysis)
  • rise in liver enzymes (ALT)-drug induced hepatitis
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5
Q

What are the contra-indications

A
  • Caution hepatic impairment
  • reduced renal impairment
  • avoid in pregnancy/ breastfeeding
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6
Q

What are the interaction

A

inhibitors (AMIODARONE, ITRACONAZOLE, MACROLIDES, PROTEASE INHIBITORS, DILTIAZEM), AMLODIPINE

Grapefruit juice

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CV therapeutics (16 decks)

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