Targeted drug delivery 2

Question 1

Why would you use active targeting to deliver drugs?

Answer 1

If you are not targeting cancer or for TDDs that are too small to accumulate via the EPR effect

Question 2

What is often upregulated in certain disease states?

Answer 2

Cell surface anitgens

Question 3

What can be used against antigens to target specifically diseased cells?

Answer 3

Antibodies

Question 4

What is over expressed in many cancers(especially breast cancer)?

Answer 4

HER2

Question 5

What is HER2?

Answer 5

A transmembrane glycoprotein

Question 6

What is ADEPT?

Answer 6

Antibody-directed enzyme prodrug therapy.
An antibody developed against a tumour antigen is linked to an enzyme and injected into the blood, resulting in selective binding of the enzyme in the tumour. When the discrimination between tumour and normal tissue enzyme levels is sufficient, a prodrug is administered into the blood circulation, which is converted to an active cytotoxic drug by the enzyme, only within the tumour.

Question 7

What 2 molecules are widely used in biology for detection and purification of biomolecules?

Answer 7

Biotin

Avidin

Question 8

What has biotin been used for?

Answer 8

Clinically to diagnose and treat tumours

Question 9

What is the luteinising hormone releasing hormone receptor overexpressed in?

Answer 9

Ovarian and some other cancers

Question 10

What are integrins?

Answer 10

Cell surface glycoproteins that mediate cell-cell and cell-matrix interactions

Question 11

Ligands that bind to integrins can be used to what?

Answer 11

Specifically target drugs to tumours

Question 12

Magnetism can be used for what?

Answer 12

Targeting and release of drugs