6: Arterial thrombosis and anti-platelet drugs Flashcards Preview

Haematology Week 2 2018/19 > 6: Arterial thrombosis and anti-platelet drugs > Flashcards

Flashcards in 6: Arterial thrombosis and anti-platelet drugs Deck (18)
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1

What blood components are involved in arterial thrombosis?

Platelets

2

What are three forms of arterial thrombosis?

MI

Stroke

Peripheral vascular disease e.g intermittent claud

3

What disease process often co-exists with arterial thrombosis?

Atherosclerosis

formation of fatty plaques in the lining of blood vessels which can rupture, initiating thrombosis and embolism

4

Atherosclerotic plaques are rich in ___.

cholesterol

5

Why is blood pressure an important risk factor for arterial thrombosis?

Increased pressure = Increased likelihood of plaque rupture

6

Which blood components bind to ruptured plaques in arterial thrombosis?

Platelets

7

What are four important cardiovascular risk factors for arterial thrombosis?

HTN

SMOKING

HIGH CHOLESTEROL

DIABETES

8

Which cells produce platelets?

Megakaryocytes

9

What chemicals are released from platelets to increase aggregation?

Thromboxane A2 (target of aspirin)

ADP (target of clopidogrel and prasugrel)

Ca2+

10

What aspects related to the vessel wall cause thrombosis in

a) arteries

b) veins?

a) Atheromas

b) Valves

11

What binds to platelets after they aggregate at the site of injury?

Platelet granules (ADP, thromboxane A2)

Von Willebrand's factor

Clotting factors

 

12

How does aspirin inhibit primary haemostasis?

Cyclo-oxygenase (COX) inhibitor

COX converts arachidonic acid to prostaglandins (NSAID part)

Prostaglandins are converted to thromboxane A2

so aspirin inhibits inflammation AND primary haemostasis

13

What are some side effects of aspirin?

Bleeding

Peptic ulceration

Bronchospasm (re: aspirin asthma)

14

Why is aspirin avoided in patients with asthma?

Bronchospasm

15

Which antiplatelet drugs are more potent than aspirin?

How do they work?

Clopidogrel

Ticagrelor

Prasugrel

Target ADP, which facilitates platelet aggregation

16

Which monoclonal antibody is used as an anti-platelet drug?

Abciximab

they have literally run out of names

17

Which protein does abciximab act on?

Glycoprotein IIb/IIIa

involved in platelet aggregation

18

How long before surgery should anti-platelet drugs be stopped for?

7 days pre-surgery