6 - Cell division Flashcards

(53 cards)

1
Q

Cell cycle stages (5)

A
M
G0
G1
S
G2
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2
Q

What happens in the M phase of the cell cycle? (3)

A

Cell growth stops
Mitosis (PMAT)
Cytokineses

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3
Q

What happens in the G0 phase of the cell cycle?

A

The cell may go through:
Apoptosis (programmed cell death)
Differentiation
Senescence (cell can only divide a certain n.o of times)

Some cells can be in the cycle indefinitely

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4
Q

What happens in the G1 phase of the cell cycle? (4)

A

Cell grows
TRANSCRIPTION of genes - make RNA
Protein synthesis
Organelles duplication

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5
Q

G1 CHECKPOINT (4)

A
CHECK FOR:
cell size
DNA damage
growth factors 
nutrients
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6
Q

What happens in the S phase of the cell cycle? (4)

A

DNA replicates
|—-> therefore each chromosomes has a pair of identical sister chromatids.
Phase happens quickly
|—-> because the exposed DNA are exposed and are susceptible to mutagen agents.

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7
Q

What happens in the G2 phase of the cell cycle? 5

A

Cell grows

Protein microtubles reassemble into spindle fibres.

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8
Q

G2 CHECKPOINT (3)

A

CHECK FOR:
cell size
DNA replication
DNA damage

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9
Q

Stages of mitosis (4)

A

Prophase
Metaphase
Anaphase
Telophase

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10
Q

Interphase

A

During interphase:
DNA replicated and checked
Protein synthesis occurs in the cytoplasm
Mitochondria grow and divide

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11
Q

Prophase

prepare

A

Chromosomes copied to form 2 chromatids
Chromosome condense
Nuclear envelope breaks down
Centrioles move to opposite poles of the cell
Spindle fibres extend to the middle of the cell

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12
Q

Metaphase

middle

A

Chromosomes line up at the equator of the cell forms metaphase plate.
Spindle fibres attaches to the centromere of the chromosomes.

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13
Q

Anaphase

away

A

Spindle fibres contract - split the centromere - chromatids are separated - dragged to poles - centromere lead
Complete set of chromosomes at each pole

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14
Q

Telophase

two

A

Chromatids reach the poles and uncoil
Nuclear envelope reforms - forming 2 nuclei
Cytokinesis follows

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15
Q

Importance of mitosis (3)

A

Assexual reproduction
Growth of cells
Replication and repair of cells

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16
Q

Importance of Meiosis (1)

A

To produce sex cells (gametes)

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17
Q

Prophase I

A

Chromatin condense & chromosome supercoils
Nuclear envelope breaks down
Chromosomes are in HOMOLOGOUS pairs = Bivalents
Chromatids entangle = Crossing over

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18
Q

Metaphase I

A

Chromosomes attach at the equator of the spindle - joined at the centromere
The homologous pairs are arranges randomly = Independent assortment

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19
Q

Anaphase I

A

Members of each homologous chromosomes are pulled apart by motor proteins
The crossed-over areas separate at the chiasmata leading to an area of swapped alleles/chromosomes

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20
Q

Telophase I

A

Two new nuclear envelope form and the cell divides via cytokinesis
Each new nucleus has half the number of chromosomes as the original but still has two chromatids.

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21
Q

Prophase II

A

The nuclear envelope breaks down
Chromosome coil and condense
The chromosomes are no longer identical due to the crossing over from P1 = Independent assortment
Spindle forms

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22
Q

Metaphase II

A

The chromosome attach to the spindle (by the centromere) and pilled to the metaphase plate
Chromatids are randomly arranged

23
Q

Anaphase II

A

Centromeres divide
Chromatids are pulled apart by motor proteins - towards the poles
Chromatids are randomly segregated

24
Q

Telophase II

A

Nuclear envelope form around 4 haploid cells

25
Differentiation
Process which stem cell become specialised into different types of cells.
26
Erythrocytes (Red Blood Cells) ANIMAL
Function: Transport oxygen around the body Features: Biconcave shape - increase surface area to volume ratio Flexible - Squeeze through nervous capillaries
27
Neutrophills (White Blood Cells) ANIMAL
Function: ingest invading pathogens Features: Multi-lobbed nucleus Attracted to infection sites by chemotaxis Granular cytoplasm ---> contains lysosomes ---> contains enzymes ---> which attack pathogens
28
Spermatozoa ANIMAL
Function: Deliver genetic material to the female gamete Features: Flagellum - move quicker/easier Many mitochondria - provide energy and propel the cell Acrosome - contains digestive enzymes ---> digest layers around the ovum ---> allow sperm to penetrate
29
Palisade Cells PLANT
Function: Absorb large amount of light for photosynthesis Features: Cells are rectangular - easy top pack many in a continuous layer Thin cell wall - increased rate of diffusion Large vacuole - to maintain turgor pressure
30
Root Hair Cells PLANT
Function: Absorb water and mineral ions from the soil Features: Long root hairs - to maximise the water uptake from the soil
31
Guard Cells PLANT
Function: Necessary for CO2 to enter the plant for photosynthesis to occur Features: lose water ---> less swollen ---> more osmotic forces
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4 main tissue types
Epithelial Connective Muscle - made of cells specialised to contract and move Nervous - made of cells specialised to conduct electricity
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Squamous Epithelium
Function: Allows diffusion to occur Features: Thin, flat cells - allows rapid diffusion Forms the lining of the lungs allows diffusion of oxygen into the blood
34
Ciliated Epithelium
Function: Traps and swipes away bacteria Features: 'Hair-like' structure - move together not allowing substances to pass Goblet cells ---> release mucus = trap any unwanted particles
35
Cartilage
Function: Prevents bones from rubbing against each other causing damage Features: Firm, flexible - composed of chondrocyte cells Contains proteins - elastin and collagen
36
Muscle
Function: Helps move and support the body Features: Can contract - to move bones ---> to move the body
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Epidermis
Function: Covers the surface of plants Features: Waxy cuticle - reduce water loss
38
Xylem & Phloem
Function: Responsible for transport of water/minerals via the cell. Responsible for transport of organic molecules. Features: Elongated,dead cells Strengthened with lignin - provides support for the plant Sieve tubes - separates the sieve plates
39
Stem Cells
Undifferentiated cells that are not specialised. | Undergo cell division repeatedly
40
Stem cells are necessary for ...
Growth Development Tissue repair
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Do stem cells need to controlled? Why?
If stem cells do not divide fast enough then tissues are not replaced efficiently enough = ageing uncontrolled divisions --> form tumors --> development of cancer
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Stem Cell Potency
The stems cells ability to divide into different cell types | Greater of number of cells = greater potency
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Totipotent
These stem cells can differentiate into any type of cell
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Pluripotent
These stem cells can form all tissue types but NOT whole organism
45
Multipotent
These stem cells can only form a range of cells within a certain tissue type
46
Replacement of erythrocytes
Short lifespan around 120 days therefore need to be replaced constantly Bone marrow produces 3 billion/kg (body mass) to keep up with the body
47
Replacement of neutrophils
Live for 6 hours Produce 1.6 billion/kg/hr This increases during infection
48
Embryonic Stem Cells
Present a a very early stage of embryo development and are totipotent
49
Tissue Stem Cells
Present in life from birth | Stem cells can harvest in the umbilical cord
50
Sources of plant stem cell
Present in meristematic tissue in plants. | Located between the phloem and the xylem this is called vascular cambium
51
Stem cells have been transported into certain areas to help treat patients, certain diseases;
``` Heart disease Type 1 diabetes Parkinson's disease Alzheimer's disease Muscular degeneration Birth defects Spinal injuries ```
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Also stem cells are used in:
The treatment of burns Drug trails Developmental biology
53
Ethics of stem cells:
Embryos were donated by those left over after fertility treatment by the new law dictates that the embryos be created in a lab. This holds back the success of treatment of incurable diseases