6. Diabetic Eye Disease Flashcards

(54 cards)

1
Q

How to we classify diabetic retinopathy

A

Non- proliferative
- mild
- moderate
- severe

Proliferative e

+/- maculopathy

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2
Q

What is diabetic maculopathy?

A

It refers to any signs of diabetic retinopathy occurring within the macula.

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3
Q

At what stage of diabetic retinopathy can maculopathy occur?

A

Maculopathy can occur at any stage of diabetic retinopathy.

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4
Q

What is the significance of seeing diabetic retinopathy signs temporal to the optic disc with a direct ophthalmoscope?

A

It indicates diabetic maculopathy, as the macula lies temporal to the optic disc.

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5
Q

Why is identifying signs of diabetic maculopathy with a direct ophthalmoscope challenging?

A

The direct ophthalmoscope has a very narrow field of view, making it harder to assess the entire retina, especially subtle macular changes.

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6
Q

What are hard exudates in NPDR, and what causes them?

A

Hard exudates are yellow lesions caused by precipitation of protein and lipid from damaged microvasculature.

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7
Q

What are the earliest visible signs of NPDR?

A

Microaneurysms or dot hemorrhages are typically the earliest visible signs of NPDR.

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8
Q

What are blot hemorrhages, and what do they indicate in NPDR?

A

Blot hemorrhages are larger, deeper retinal hemorrhages, indicating more severe vascular leakage in NPDR.

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9
Q

What are cotton wool spots, and what do they indicate in NPDR?

A

Cotton wool spots are fluffy white retinal lesions caused by microinfarctions of the retinal nerve fiber layer, indicating retinal ischemia and moderate to severe NPDR.

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10
Q

What rule is used to define severe NPDR?

A

The 4-2-1 rule is used to define severe NPDR.

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11
Q

What does the “4” in the 4-2-1 rule for severe NPDR represent?

A

Severe retinal hemorrhages or microaneurysms in all 4 quadrants of the retina.

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12
Q

What does the “2” in the 4-2-1 rule for severe NPDR represent?

A

Venous beading in at least 2 quadrants, indicating advanced retinal vascular damage.

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13
Q

What does the “1” in the 4-2-1 rule for severe NPDR represent?

A

Presence of intraretinal microvascular abnormalities (IRMA) in at least 1 quadrant.

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14
Q

What is the clinical significance of identifying severe NPDR using the 4-2-1 rule?

A

Severe NPDR has a high risk of progressing to proliferative diabetic retinopathy (PDR) and requires urgent referral to ophthalmology.

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15
Q

What is the hallmark sign of Proliferative Diabetic Retinopathy (PDR)?

A

The presence of fibrovascular complexes, which are new, fragile blood vessels growing on the retinal surface.

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16
Q

What happens to the new vessels in advanced PDR?

A

The new vessels are replaced by fibrosis, forming contracting fibrovascular membranes.

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17
Q

What complication can arise from contracting fibrovascular complexes in PDR?

A

They can lead to tractional retinal detachments, pulling the retina away from the back of the eye.

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18
Q

What should you consider when a diabetic patient has poor vision and “lots of white stuff” on the retinal surface?

A

Suspect fibrovascular proliferation and retinal traction in advanced PDR, especially if the white material obscures normal retinal anatomy.

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19
Q

How often should screening be done?

A

yearly

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20
Q

When to start screening

A
  • Type 1 DM at puberty
  • Type 2 DM at diagnosis
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21
Q

What is the preferred screening technique for diabetic retinopathy in most settings?

A

Visual acuity assessment + grading of fundus photographs by trained optometrists.

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22
Q

How is diabetic retinopathy screening typically done in the private sector?

A

Through a private optometrist who performs visual acuity testing and fundus photography.

23
Q

How is diabetic eye screening commonly conducted in the public sector?

A

Via the optometry screening service at local day hospitals, using fundus photography and visual acuity testing.

24
Q

What is the backup screening method if fundus photography is not available?

A

Visual acuity assessment + pupil dilation with Tropicamide + direct ophthalmoscopy by a GP.

25
Management by GP
Optimize diabetic control Treat associated hypertension Treat associated hyperlipidaemia Better control of these factors better visual outcomes
26
Referral of mild or moderate NPDR without maculopathy
Refer routinely if not confident of the grade of retinopathy
27
Referral of Diabetic maculopathy
Refer within 1 month
28
Severe NPDR referral
refer within 1 month
29
Proliferative diabetic retinopathy referral
refer within 1 week
30
What are the treatment options for diabetic maculopathy managed by an ophthalmologist?
Focal laser Grid laser Intravitreal Avastin (Bevacizumab) injections
31
What is PRP and when is it used in diabetic eye disease?
Panretinal photocoagulation (PRP) is used to treat proliferative diabetic retinopathy by reducing neovascularisation.
32
What is PPV and when is it indicated in diabetic retinopathy?
Pars plana vitrectomy (PPV) is performed for advanced proliferative diabetic retinopathy, especially with vitreous haemorrhage or tractional retinal detachment.
33
What type of laser is used for treating diabetic maculopathy?
An argon laser machine on a low power setting is used.
34
How does focal or grid laser therapy treat maculopathy?
Burns are applied to the affected macular areas to stimulate the retina to resorb oedema, without causing retinal damage.
35
Are laser scars visible on fundoscopy after focal/grid laser for maculopathy
No, laser scars are not visible on fundoscopy because the treatment is low intensity and non-damaging.
36
What class of drug is Avastin and what is its mechanism of action in diabetic maculopathy?
Avastin is an anti-VEGF (vascular endothelial growth factor) agent. It stabilizes retinal blood vessel walls, which leads to resorption of oedema
37
How is Avastin administered for diabetic maculopathy?
It is injected into the vitreous cavity in a sterile outpatient procedure.
38
What type of laser and setting is used for PRP in diabetic retinopathy?
An argon laser machine on a high power setting is used.
39
Where are the laser burns applied during PRP?
Burns are applied to the peripheral retina, outside the macula.
40
How does PRP help in proliferative diabetic retinopathy?
PRP reduces the oxygen demand of the retina, which causes the new abnormal vessels (neovascularisation) to regress.
41
Are PRP laser scars visible on fundoscopy, and if so, where are they easiest to see?
Yes, laser scars are visible as depigmented or hyperpigmented spots. They are easiest to find nasal to the optic disc on direct ophthalmoscopy.
42
When is pars plana vitrectomy (PPV) indicated in diabetic retinopathy?
PPV is indicated in patients with vitreous haemorrhage or fibrovascular complexes causing tractional retinal detachment.
43
Where are the surgical ports placed during PPV?
Ports are placed through the pars plana of the eye.
44
What is a key sign of neovascular glaucoma?
New vessels on the iris (NVI) — these new vessels are not visible with a direct ophthalmoscope.
45
How do new vessels on the iris lead to neovascular glaucoma?
NVI can obstruct the angle of the eye, causing increased intraocular pressure and neovascular glaucoma.
46
How does a patient with neovascular glaucoma typically present?
With a painful red eye and hazy cornea due to high intraocular pressure.
47
What is third nerve palsy?
It is a paralysis or weakness of the oculomotor nerve (cranial nerve III) causing impaired eye movements, ptosis, and possibly pupil involvement.
48
What are the main types of third nerve palsy?
Pupil-sparing (Ischemic) third nerve palsy Pupil-involving third nerve palsy
49
What causes pupil-sparing third nerve palsy?
Usually caused by microvascular ischemia (e.g., diabetes, hypertension). The pupillary fibers are spared because they are located peripherally and receive a different blood supply.
50
What causes pupil-involving third nerve palsy?
Usually caused by compressive lesions (e.g., posterior communicating artery aneurysm, tumor) that affect the superficial pupillary fibers causing pupil dilation.
51
Why is pupil involvement important in third nerve palsy?
Because pupil involvement suggests a compressive cause, which is an ophthalmic emergency needing urgent investigation.
52
If a patient presents with diabetic ketoacidosis and proptosis
also cosider mucor mycosis , its' a life threatening condition
53
What is mucormycosis?
Mucormycosis is a rapidly progressive, invasive fungal infection caused by fungi in the order Mucorales. It primarily affects immunocompromised patients, especially those with uncontrolled diabetes or ketoacidosis.
54
What are the common clinical features of mucormycosis?
Facial pain and swelling Nasal congestion or black nasal discharge Fever Orbital involvement: proptosis, ophthalmoplegia, ptosis, third nerve palsy with pupil involvement Vision loss Necrotic black eschar on the palate or nasal mucosa