6. Learning From The Dead Flashcards

(50 cards)

1
Q

Forensic pathology

A

> The study of injuries and or diseases to determine the cause of death

  • A post-mortem investigation of sudden or unexpected death or trauma to the living
  • Speacilisit knowledge of injuries and diseases to determine cause of death
  • Conduct autopsis
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2
Q

Role of forensic pathologist

A
  • Confirm death has occurred
  • Estimate time since death
  • Ensure positive identification
  • Record injuries and natural disease if any
  • Determine the cause of death
  • Form an opinion on possible manner of death through reconstruction of events
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3
Q

5 possible Manner of death

A
Natural 
• Accidental 
• Homicide 
• Suicide 
• undetermined
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4
Q

What is an autopsy

A

• Inspect body internally or externally

—> Autopsy (necropsy and post-mortem examinations are synonymous) means to ‘see for oneself’.
• It is an opportunity to directly inspect and analyse the organs.

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5
Q

2 types of autopsy

A
  • The clinical or academic autopsy:

* The medico-legal or forensic autopsy:

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6
Q

• The clinical or academic autopsy:

A

○ The medical attendants, with the consent of relatives, seek to learn the extent of the disease for which they were treating the deceased patient.
○ Study disease and treatment given to patient

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7
Q

• The medico-legal or forensic autopsy:

A

○ Performed on the instructions of the legal authority responsible for the investigation of sudden, suspicious, unnatural or criminal deaths.
○ Legal requirement e.g. when attending can’t determine cause of death
○ Consent is not required for this

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8
Q

Physical evidence

A

—> Before an autopsy can occur, a medical examiner will search for any physical evidence on the body

  • Weight
  • Height
  • Fingerprints
  • Physical distinguishing charactersitics
  • Physical evidence e.g. bite marks
  • Biological evidence – insect or qounds
  • Chemical evidence – alcohol or drugs
  • Physioloigcal evidence – bone, hair, blood
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9
Q

Rigor mortis

A

—-> Stiffening of body because of lack of oxygen in muscle cells.
• Begins around 4 hours after death.
• Begins in eyelids and small muscles of jaw, then to neck and rest of body.
• Sits in more quickly when there has been a violent struggle (uses up energy in muscles)
• Completely sits in within 12 hours after death and lasts around 36 hours before body returns to non-rigid state
Impacted by temperature and environment

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10
Q

Rigor mortis - time period

A
Less than 3 hours – warm 
3 - 6 hours – warm but stiff
6 hours – cool but stiff
36 hours – cold and no stiffness
• Use to determine cause of death
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11
Q

Liver mortis

A

–> Discoloration of skin after death = blue to purple areas
• Caused by gravity-induced stagnation and settling of red blood cells in small blood vessels.
• Commonly referred to as “lividity
• Occurs 6-8 hours after death.
• Occurs in parts of body closest to ground by effect of gravity

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12
Q

Types of wounds

A
  • Lacerations - irregular tearing of tissue that is contaminated wit bacteria
  • Incised wounds – not deep but caused by sharp items
  • Puncture wounds- sharp pointed object
  • Abrasions - rubbing of skin
  • Contusions – rupture of small vessels
  • Gunshot wounds – determine type of firearms distance of shooter
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13
Q

Steps of an autopsy

A
Rigor mortis and liver mortis 
• Internal and external 
• Opening of trunk: 
• Y incision 
• Open rib cage 
• Remove organs 
• Specimens for testing – fixed with formaldehyde
• Brain stored in 10% formaldehyde for 2 weeks 
• closing
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14
Q

Purpose of an autopsy

A

• find Difference between antimortem and post mortem body

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15
Q

Why examine dead bodies

A

To:
– Understand the anatomy of the body
– Correlate structure to function
– study the effects of disease processes and cause of death
Assess the effect of therapeutic interventions
• Find evidence for criminal proceedings

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16
Q

4 Common affected areas of sudden death

A
  • Head ‘
  • Heart
  • Blood vessels
  • Lungs
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17
Q

Head - sudden causes of death

A

Extradural haemorrhage

Subdural haemorrhage

Sub arachnoid haemorrhage

Intracerebral haemorrhage

Intracranial aneurysm

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18
Q

Meninges - structure and definition

A
Meninges – membranous covering of connective tissue that support brain and spinal cord 
	• Made of 3 layers
		○ Periosteal dura mater
		○ Meningeal dura mater
		○ Arachnoid mater
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19
Q

Extradural haemorrhage

A

– collection of blood between the skull out outer layer of the dura (periosteal dura).
○ Occurs due to head trauma and can lead to sudden death

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20
Q

Subdural heamorrhage

A

– collection of blood in the subdural space due to bleeding from vein in the area – connection of blood between arachnoid dura layer and meningeal dura mater
○ Occurs due to head trauma and can lead to sudden death
○ This can increase pressure on underlying brain tissue

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21
Q

Sub arachnoid haemmorhage

A

– collection of blood in sub arachnoid space
○ Associated with rupture of aneurysm due to dilation or weakness of blood vessel
○ Pressure and compression on brain tissue
○ Related to trauma, infection, neoplasma

22
Q

Intracerebral haemoorhage

A
  • haemorrhage within brain tissue

○ Space occupying tissue, causes compression and pressure on brain, affecting function

23
Q

Intracranial aneurysm

A

– weakness in the wall

○ Trauma or hypertension leads to rupture and death

24
Q

Stroke

A

—> clinical manifestation of blockage or disruption to brain tissue

25
2 types of stroke
Ischaemic | Haemorrhagic
26
Ischaemic stroke
• Thrombosis, embolism, narrowing, blocking lumen, reudced blood flow, blood flow infarction and ischaemic defects
27
Haemorrhagic stroke
• Aneurysm, blood spreads around brain tissue may damage cell and lead to stroke
28
Neuropathology
Cellular pathology to – Central nervous system – Peripheral nerves – Muscle
29
Neuropathology - Relevant autopsies – determine if cause is
* Trauma | * Neurodegenerative disease
30
Alzhheimers disease
• Neurodegenerative disease • Alzheimer patient has atrophy (decrease in structure size) ○ Cortical atrophy – common withg aging Atrophic brain – gyri of brain are shrunken and suclcus are widened
31
Lewy body dementia
* Microscopic examiantion of tissue * Associated with progressive diseases that affect mental abilities and hallucinates e.g. like parksinsons disease Lewy bodies – basophilic material accumulated in brain tissue
32
2 neurodegenerative diseases
Alzhheimers disease | Lewy body dementia
33
Heart
Coronary artery thrombosis Valvular disease Cardiomyopathies
34
Coronary artery thrombosis
• Coronary artery thrombosis – thrombis in artery occluding all artery
35
Valvular disease
* Aortic valve stenosis | * Associate with degernative changes and aging, defects in abnormal valves due to calcification, thickness and fibrosis
36
Cardiomyopathy
---> group of disorders that are Non-ischaemic, non-inflammatory disease of heart muscle
37
2 types of cardiomyopathy
– Hypertrophic = thickened heart muscle in ventricle and intraventricle septum ,impact lumen size – Dilated = dilation within ventricular lumen, weakened, increase lumen diameter Both affect pumping of blood
38
Hypertrophy
* Left ventricular hypertrophy – increase in size of left ventricle affects lumen and pumping mechanism * Right ventricular hypertrophy – reduce in lumen size, increase in thickness of muscle in heart wall
39
dilatation
• Dilated cardiomyopathy – no change in thickenes but there is dialtion, enlargement of ventricle which affects relaxing and filling mechanism of heart
40
Blood vessels
Ruptured abdominal aortic aneurysm
41
Ruptured abdominal aortic aneurysm
• Ruptured abdominal aortic aneurysm = weakness in wall due to atherosclerosis (underlying cause) ○ Causes dilation of the vessel and increases pressure = rupture and death
42
Lung
Pulmonary embolism Bronchopneumonia Viral pneumonia Lung carcinoma Metastatic tumour within the lung Perionitis
43
Pulmonary embolism
presence of thrombi emboli (underlying cause can be cancer) | ○ Causes obstruction of main vessel , large pulmonary artery = death
44
Bronchopneumonia
○ White b=patches around bronchi and bronchioles ○ Can lead to death ○ Grey to yellow dry elevated lesions
45
Viral pneumonia
○ Patchy areas of inflammation congestion, necrosis, fibrosis, hemorrhagic areas ○ Within the interstitium (tissue of the lung)
46
Lung carcinoma
depends on type of cancer and position of cancer in lung ○ Squamous cell carcinoma – occurs in periphery (A) ○ Adenocarcinoma = occurs in lobe of lung (B) ○ Asbestosis (C) ○ Different cancers change lung different in image
47
Metastatic tumour within the lung
○ Multiple nodules affecting lung, associated with metastasis – cancer in different part of body ○ Find out from which organ the metastasis has happened
48
Peritonitis
yellowsish disclouration in peritioneum ○ Happens in response to irritation of peritoneum and accumulation of pepinasoxidase ?? ○ If extensive it can lead to death
49
Paediatric pathology
• Paediatric pathologists are trained in paediatric surgical pathology and autopsy. • Paediatric autopsies – reasons for it – Deaths in utero – Death in infancy eg sudden infant death syndrome – Suspicious deaths
50
Paediatric autopsies
``` Macroscopic examination • Microscopic examination • Toxicology • Microbiology – In utero infections – Sudden infant death • Genetic studies – Karyotyping ```