6-Malignant Neoplasms of Bone

Question 1

What is an Osteosarcoma?

Answer 1

malignant neoplasm of osteoblastic cells that produces osteoid matrix (may calcify)

Question 2

What is the most common primary malignancy of bone?

Answer 2

Osteosarcoma

7% occurs in bone

Question 3

Osteosarcoma clinical features?

Answer 3

swelling and pain
loosening of adjacent teeth
paresthesia/anesthesia

Question 4

Osteosarcoma radiographic appearance?

Answer 4

ill-defined lesion that blends into surrounding bone
symmetrical widening of periodontal membrane space
spiked root form
irregular root resorption
SUNBURST/SUN RAY appearance

Question 5

What is Juxtacortical Osteosarcoma?

Answer 5

Osteosarcoma arising on cortical surface rather than in an intramedullary location
Local recurrence a major problem

Question 6

What is Chondrosarcoma?

Answer 6

relatively unusual lesion of the jaw, malignant bone neoplasm producing cartilage but not bone

Question 7

Chondrosarcoma clinical features?

Answer 7

Most over 50 to 6th/7th decades
males slightly more affected
non-painful
loosening of adjacent teeth
Paresthesia/anesthesia
Mx>Mn

Question 8

Chondrosarcoma Tx and Prognosis?

Answer 8

Recurrence can take years so 5 y/o survival not a good sign

Question 9

What is Ewing’s Sarcoma?

Answer 9

Genetic defect
Primary bone tumor in children and adolescents
dismal prognosis