6. Mycoplasma & Chlamydia

Question 1

Does chlamydiae obligate intracellualr pathogens?

Answer 1

Yes

Question 2

How do chlamydiae differ from other bacteria?

Answer 2

• have no peptidoglycan in their cell wall
• do not produce ATP —> need host ATP —> energy parasites
• growth cycle ( biphase life cycle)

Question 3

Chlamydiae EB?

Answer 3

• elementary bodies
• extracellular form
• infective form

Question 4

Chlamydaie RB?

Answer 4

• reticulate bodies
• intercellular form
• replicative form

Question 5

Common chlamydiae pathogens?

Answer 5

• chlamydia trachomatis
• chlamydia psittaci
• chlymydia pneumoniae

Question 6

What are the Ocular infections of chlamydia trachomatis?

Answer 6

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• Trachoma (common in children, spreads by flies or fingers, imp cause of blindness)
• Adult inclusion conjunctivitis ( speards from genetalia to eye, common in sextually active young ppl, self limiting)
• Chlamydial opthalmia neonatorum ( neonates 1-3 weeks after birt, source is the mother’s birth canal)

Question 7

What are the genital infections of Chlamydiae trachomatis ? (Males)

Answer 7

• non-gonococcal urethritis

- genital ulcer & lymphadenopathy known as lymphgranuloma venereum / LGV —> Found in tropics

Question 8

What are the genital infections of chlamydaie trachomatis? (Females)

Answer 8

• urethritis & cervicitis
• endometritis & salpingitis —>
• ectopic pregnancy & infertility

Question 9

What are the respiratory infections of chlamydaie trachomatis?

Answer 9

-neonatal pneomonitis

Question 10

Chlamydia pneumonaie clinical infections?

Answer 10

• otitis media & sinusitis

- pneumonia & bronchitis

Question 11

Chlamydia psittaci clinical infections?

Answer 11

• Psittacosis or ornithosis
• non- human pathogen / zoonotic infection
• droplet infection
• bird handlers
• atypical pneomonia

Question 12

What are mycoplasma?

Answer 12

*Bacteria that lack cell wall and can grow in rich artificial media
* 3 species are s=associated w/ infection in humans
1- mycoplasma hominis
2- ureaplasma urealyticum
3- mycoplasma pneumoniae

Question 13

What are the respiratory infections of mycoplasma pneumoniae?

Answer 13

Atypical pneumonia

• children are more affected
• more during summer
• prominant X-ray findings
• disease course >2 weeks
• HEMOLYTIC ANEMIA

Question 14

Mycoplasma pneumoniae extrapulmonary manifestion?

Answer 14

• hemolytic anemia

- myocarditis

Question 15

Diagnosis of mycoplasma pneumonia?

Answer 15

• serology
• IgG & IgM
• Rapid diagnosis
• Molecular
• Cold agglutinin test

Question 16

Treatment of mycoplasma pneumonia?

Answer 16

• erythromycin

- shouldnt use any antibiotic act on cell wall, why?

Question 17

What are the genital infections of mycoplasma hominis & ureaplasma urealyticum? (Males - females)

Answer 17

Males:
-non-gonococcal urethritis 
Females:
- pelvic inflammatory disease PID 
- abortion & pretern labor 
- stillbirth