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Dermatology > Drug Eruptions and the Skin in Systemic Disease > Flashcards

Drug Eruptions and the Skin in Systemic Disease Flashcards

1
Q

Causes and features of maculopapular drug eruptions (3)

A

penicillins, cephalosporins, anti-epileptics

generalised erythematous macules and papules +/- fever and raised eosinophils

eruption w/i 2wks of taking drug

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2
Q

Causes and features of urticarial eruptions (4)

A

wheals+/- angiodema and anaphylaxis

rapid onset after taking drug

immune (IgE mediated):

  • penicillin
  • cephalosporin

non-immune (mast cell degranulation):

  • morphine
  • codeine
  • NSAIDs
  • contrast
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3
Q

Presentation of erythema multiforme (2)

A

symmetrical target lesions on palms, soles and limbs

occur 1-2wks after insult

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4
Q

Causes of erythema multiforme (3)

A

INFECTIONS: main cause-HSV and mycoplasma

drugs-SNAPP:

  • sulphonamides
  • NSAIDs
  • allopurinol
  • phenytoin
  • penicllin

idiopathic

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5
Q

Features of SJS (2)

A

more severe form of erythema multiforme

blistering mucosa: conjunctival, oral and genital

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6
Q

Features of TEN (3)

A

severe form of SJS

nearly always a drug reaction

increased risk in HIV+ve patients

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7
Q

Presentaiton of TEN (3)

A

severe mucosal ulceration

widespread erythema followed by epidermal necrosis w. loss of large sheets of epidermis

> dehydration

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8
Q

Rx and prognosis of TEN (2)

A

Rx w. Dexamethasone +IVIg

30% mortality rate

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9
Q

Features and causes of erythema nodosum (5)

A

painful, blue-red lesions on anterior shins

causes-3Ss:

  • sarcoid
  • sulphonamides
  • strep

also: IBD, TB, bechet’s, OCP

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10
Q

Features of pyoderma gangrenosum (3)

A

wide, deep ulceration w. violaceous border, purulent surface and undermined edge

commonly occurs on legs

heals w. cribriform/pitted scars

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11
Q

Assoc. of pyoderma gangrenosum (5)

A

IBD

AIH

RA

Wegener’s

Leukemia

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12
Q

Rx of pyoderma gangrenosum

A

high-dose systemic steroids

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13
Q

Features and association of vitilligo (3)

A

chalky, white patches w. hyperpigmented borders

itch under sunlight

assoc. w. autoimmune conditions

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14
Q

Features of livedo reticularis (3)

A

persistent, mottled, red-blue lesions which don’t blanch

found mainly on legs

triggered by cold

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15
Q

Causes of livedo reticularis (4)

A

idiopathic

vasculitis: SLE, RA, PAN
obstruction: antiphospholipid, cryoglobulinaemia

Sneddon’s syndrome: Livedo reticularis+CVAs

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16
Q

Skin manifestation of rheumatic fever

A

erythema marginatum

17
Q

Lyme disease manifestation

A

erythema chronicum migrans

18
Q

Crohn’s manifestations (3)

A

peri-anal ulcers and fistulae

erythema nodosum

pyoderma gangrenosum

19
Q

Manifestations of dermatomyositis (5)

A

heliotrope rash on eyelids

Shawl sign (macular rash)

Gottron’s papules

mechanic’s hands

nailfold erythema, telangiectasia

20
Q

Manifestations of DM (6)

A

ulcers

candida

Kylre disease

necrobiosis liploidica (shins)

granuloma annulare (hands and feet)

Acanthosis nigricans

21
Q

manifestations of sarcoid (5)

A

erythema nodosum

erythema multiforme

lupus pernio

red/violet plaques

hypopigmented areas

22
Q

manifestations of coeliac disease

A

dermatitis herpetiformis (elbows)

23
Q

Grave’s

A

pre-tibial myxoedema

24
Q

RA

A

rheumatoid nodules

vasculitis (palpable purpura)

25
Q

systemic sclerosis (5)

A

calcinosis

raynaud’s

(esophageal dysmotility)

sclerodactyly

telangiectasia

generalised skin thickening

26
Q

Liver disease (7)

A

palmar erythema

spider naevi

decreased secondary sexual hair

jaundice

excoriations

gynaecomastia

bruising

27
Q

ESRD (4)

A

pruritus

xerosis (dry skin)

pigment change

bullous disease

28
Q

skin manifestations of neoplasms (4)

A

dermatomyositis

acanthosis nigricans

thrombophlebitis migrans

acquired ichthyosis-thick, scaly skin

Dermatology (6 decks)

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