Doug Flashcards
Give 3 examples of an inactivated virus vaccine
Rabies
Feline leukaemia virus
Foot and mouth disease virus
What’s the difference between ISCOM and other types of adjuvant ?
ISCOM activates both adaptive and innate immune response
Most adjuvants only stimulate the adaptive
Which antibody is most associated with a response to parasites?
IgE
Which antibody is most associated with allergic reactions?
IgE
Which cytokines produced from T helper 1 cells induce IgG subclass during class switching
IFN gamma
Which cytokines produced by t helper 2 cells stimulate B cells to produce IgE subclass during class switching
IL4, IL13, IL5
Regulatory T-cell reduce inflammation by producing IL-10 and TNF-beta. What affect does this have on class switching?
Reduces IgE, stimulates IgA production
Why is degranulation from Mary cells always sub-optimal?
Multiple types of antibody bound to cell membrane, multiple variable regions. Only possible to cross link 10% of antibodies when contacting antigen, as all different: therefore only 10% needed for them to degranulate and produce histamine
What is the difference between vertical transmission and pseudo-vertical transmission
Vertical transmission is direct transmission of disease from one generation to the next
Pseudo is transmission to the next generation, but young pick it up during perinatal period, environmental factors
What is the significance of the weight of an aerosol droplet in terms of respiratory infection
Will alter where it settles on resp tract. Higher molecules rest higher up and are more likely to cause disease. Lower molecules settle in alveoli, more likely to be breathed out
What are the 4 factors that affect aerosol spread?
Amount she’d,
survival of agent in environment (UV, dust inactivation)
Weather conditions : wind speed, humidity, temp, rain
Host susceptibility
