Inflammation Flashcards
1
Q
In acute inflammation, what are the inflammatory mediators
A
- IL-1
- IL-6
- TNF-alpha
2
Q
In acute inflammation, what mediates increased vascular permeability leading to fluid exudate
A
- Histamine
- Serotonin
- Bradykinin
3
Q
During acute inflammation, fibroblasts lay down collagen. This requires what cofactor
A
Vitamin C
4
Q
In acute inflammation, tissue remodeling is done by metalloproteinases . . these contain what metal
A
zinc
5
Q
Chronic inflammation is mediated by what cells
A
-mononuclear cells (macrophages and lymphocytes)
6
Q
What mediator FORMS granulomas?
What mediator MAINTAINS granulomas?
A
- IFN-gamma
- TNF-Alpha
7
Q
Neutrophil extravasation is enhanced by what factor?
A
Platelet activating factor
8
Q
What cell type plays a role in inflammation by generating fibrinogen and CRP
A
hepatocytes
