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Pathology > Coag > Flashcards

Coag Flashcards

1
Q

2 genes with greatest impact on coumadin

A

VKORC1 and CYP2C9

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2
Q

Enoxaprin, dalteparin, nadroparin, tinzaparin, danaparoid are examples of?

A

LMWH

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3
Q

Fondaparinux (Arixtra) is a

A

Direct Xa inhibitor

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4
Q

Hirudin, lepirudin, desirudin, aragtroban, bivalirudin are examples of

A

Direct thrombin inhibitors

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5
Q

Apixaban and rivaroxaban are examples of? Whats special about them?

A

direct Xa inhibitors that can be taken orally

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6
Q

Dabigatran?

A

Direct thrombin inhibitor

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7
Q

Give examples of drugs that block the P2Y12 receptor

A

Thienopyridines

  • Ticlopidine (Ticlid)
  • Clopidogrel (Plavix)
  • Prasugrel
  • Ticagrelor
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8
Q

Name the platelet inhibitor that works through downstream effects of phosphodiesterase inhibition, reduces calcium concentrations.

A

Dipyridamole

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9
Q

Aggrenox is composed of?

A

Low dose aspirin and dipyridamole

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10
Q

Name the GPIIb/IIIa inhibitors

A

Tirofiban (Aggrastat)
Eptifibatide (Integrilin)
Abciximab (ReoPro)

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11
Q

Resistance to what drug is associated with cytochrome P450?

A

Thienopyridines

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12
Q

Upshaw-Schulman syndrome

A

Familial TTP

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13
Q

Laboratory tests for HIT?

A

PF4 abs by ELISA
Serotonin Release Assay (SRA)
Heparin induced platelet aggregation assay (HIPA)

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14
Q

Antithrombin inhibits what factors?

A

2, 9a, 10a, 11a, 12a

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15
Q

SERPINC1 is a

A

antithrombin gene

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16
Q

Coumadin induced skin necrosis is associated with which thrombophilia?

A

Protein C deficiency

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17
Q

Of the anti-phospholipid syndrome, which antibody is more common and associated with arterial thrombosis? PTT is?

A

ACA syndrome

PTT is normal

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18
Q

Of the anti-phospholipid syndrome, which antibody shows prolonged PTT?

A

LAC

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19
Q

Of the anti-phospholipid syndrome, which antibody is associated with ineffective treatment with Warfarin?

A

ACA

20
Q

Glutamine for arginine substitution at position 506 in the factor V causes?

A

Activated protein C resistance (factor 5 leiden)

21
Q

A single inversion mutation of intron 22 on Xq28 has been shown to cause 40-45% of _____ in Caucasians

A

Hemophilia A

22
Q

Factor 9 leiden referns to?

A

Hemophilia B that spontaneous undergoes remission following puberty

23
Q

Which factor deficiency is tested by the clot solubility in 5 molar urea solution?

A

Factor 13

24
Q

In Amyloidosis, which factor deficiency is sometimes seen?

A

X deficiency

25
Q

What is a brodifacoum?

A

warfarin like compound present in pesticides

26
Q

Bernard Soulier is a defect in the?

A

CD42b or GP1b/5/9

27
Q

Name the 3 large platelets associated with MYH9 mutation

A 
May-Hegglin anomaly (Dhole bodies)
Fechtner syndrome (Hearing loss, cataracts, nephritis)
Sebastian syndrome ( leukocyte inclusion)
28
Q

What are the 3 platelet storage pool disorder with a abnormal dense granules

A

Hermansky-Pudlak
Chediak Higashi
Wiskott-Aldrich

29
Q

Name that storage pool disease

Chrom 10q23 ( HPS1, AP3B1, DTNBP1)
Childhood epistaxis 
oculocutaneous albinism
Complicated by pulmonary fibrosis and granulomatous colitis
Ceroid like bodies in macrophages
Common in Puerto Rico
A

Hermansky-Pudlak

30
Q

Name that storage pool disease

Ceroid bodies in granulocytes, platelets, and melanocytes
Oculocutaneous albinism
Lymphoproliferative disorders

A

Chediak-Higashi

31
Q

Name that storage pool disease

X linked
Thrombocytopenia
Eczema
Immunodeficiency

A

Wiskott-Aldrich

32
Q

Glanzman thrombasthenia is defined by

A

deficient GP2b/3a complex aka PLA1 aka CD41/CD61

33
Q

If serial dilutions results in apparent increase in factor activity, what should you consider?

A

Inhibitor

34
Q

In the platelet aggregation studies, what do you see with aspirin?

A

Decreased with
Arachidonate acid
Absent secondary wave with epinephrine and ADP

35
Q

Which coagulation factor is

not made by the liver?

A

8 (endothelial cells) and vWF (endothelial cells and megs)

36
Q

Which coagulation factor

has the shortest half life?

A

7 (6 hours)
Protein C (6 hours)
8 (12 hours)
5 and 9 (24 hrs)

37
Q

Which coagulation factor

has the longest half life?

A

13 (150 hours)

1/fibrinogen (100-150)

38
Q

Which coagulation factor is 4?

A

Calcium

39
Q

Which coagulation factor is 3?

A

tissue factor

40
Q

Whats in the alpha granules?

A 
Fibrinogen
PDFG
vWF
PF4
P-selectin
41
Q

Whats in the dense granules?

A

ADP/ATP
Serotonin (5-HT)
Ca

42
Q

GP1a/2a is a receptor for?

A

Collagen

43
Q

In gray platelet syndrome, what markers are decreased?

A

CD62 and PF4 expression on the surfacec of platelets.

44
Q

What disorder is marked by blunted aggregation with all agents except for ADP?

A

gray platelet syndrome (AR)

45
Q

Name the disorders with giant platelets

A 
Bernard Soulier
MHY9s (May Hegglin, Fechtner, Sebastian)
Gray platelet syndrome
ITP
Montreal platelet syndrome
46
Q

Diminished clot retraction time is seen in?

A

Glanzmann

Pathology (16 decks)

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