Cardiology

Question 1

Progression of atherosclerosis

Answer 1

1. Lipid laden Mphage (foam cells)- form fatty streak
2. Plaque progression- SMCs migrate into intima and proliferate
3. Plaque disruption results in thrombus formation

Question 2

Contraindications for tPA/ fibrinolysis

Answer 2

Cerebrovascular hemorrhage

Active internal bleeding

Aortic dissection

Marked HTN (systolic > 180; diastolic > 110)

Nonhemorrhagic stroke or or cerebrovascular event