Lecture 8: B-Cell Effector Responses Flashcards
Antibodies are ________ proteins present in _______ but can enter ______.
Globular
Serum
Tissues
How many binding sites do Antibody have?
At least 2 binding sites
What is an Epitope?
The part of an antigen that can actually fit into the binding site of an antibody
What is a Hapten?
Low molecular weight molecules that do not themselves stimulate an immune response but can do so when bound to a carrier protein
What is a Paratope?
The part of the antibody than can actually bind the epitope
What is cross-reactivity?
Antigen is recognised by an antibody produced to a different antigen, this is due to shared structural features that match the binding sites
What is Avidity?
The total strength of the Ab-Ag binding interaction
What is Affinity?
The strength of the interaction between a single antigen-binding site and its antigen
IgE is associated with ________________
Allergic diseases i.e. Asthma and Hay fever
What is the role of IgD?
Found on B cell surfaces but it’s function is unclear
Does the brain have immunoglobulins?
Normally no Ig in the brain
Give an overview of linked recognition:
- B cells and helper T cells must recognise epitopes of the same molecular complex in order for the T cell to provide help
- Peptides presented by MHC2 on B cells to T cells
- T cell activates the B cell which dy/dx into plasma cells
What are the 3 major functions of antibodies?
Neutralisation
Opsonisation
Complement Activation
What is Neutralisation?
- Binding of ab to toxins
- Blocking bacteria’s ability to adhere
- Bind to viruses to prevent their entry into host cells
What is Opsonisation?
Coating of a pathogen to make it more easy to digest via phagocytosis
