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Micro ID Flashcards

1
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Penicillin G

A

1) Gram-positive organisms (S. pneumoniae, S. pyogenes, Actinomyces) & syphillis; Bactericidal for gram-positive cocci, gram-positive rods, gram-negative cocci, & spirochetes; Not penicillinase resistant
2) IV Penicillin (Prototype Beta-lactam abx;Non-penicillinase resistant); Bind PNC-binding proteins; Block transpeptidase cross-linking of peptidoglycan; Activates autolytic enzymes
3) Hypersensitivity rxns; Hemolytic anemia
4) Resistance: Beta-lactamases cleave Beta-lactam ring

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2
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Penicillin V

A

1) Gram-positive organisms (S. pneumoniae, S. pyogenes, Actinomyces)
& syphillis; Bactericidal for gram-positive cocci, gram-positive
rods, gram-negative cocci, & spirochetes; Not penicillinase resistant
2) PO Penicillin (Prototype Beta-lactam abx;Non-penicillinase resistant); Bind PNC-binding proteins; Block
transpeptidase cross-linking of peptidoglycan; Activates autolytic enzymes
3) Hypersensitivity rxns; Hemolytic anemia
4) Resistance: Beta-lactamases cleave Beta-lactam ring

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3
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Methicillin

A

1) S. aureua (except MRSA; resistant d/t altered PNC-binding protein target site)
2) PNC-Resistant PNCs; Bind PNC-binding proteins; Block
transpeptidase cross-linking of peptidoglycan; Activates autolytic enzymes (=Same MOA as PNC). Narrow spectrum; Penicillinase resistant b/c of bulkier R-group
3) Hypersensitivity rxns; Interstitial nephritis (Methicillin specific)

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4
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Nafcillin

A

1) S. aureua (except MRSA; resistant d/t altered PNC-binding protein target site)
2) PNC-Resistant PNCs; Bind PNC-binding proteins; Block
transpeptidase cross-linking of peptidoglycan; Activates autolytic enzymes (=Same MOA as PNC). Narrow spectrum; Penicillinase resistant b/c of bulkier R-group
3) Hypersensitivity rxns
4) Use naf for staph!

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5
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Dicloxacillin

A

1) S. aureua (except MRSA; resistant d/t altered PNC-binding protein target site)
2) PNC-Resistant; Bind PNC-binding proteins; Block
transpeptidase cross-linking of peptidoglycan; Activates autolytic
enzymes (=Same MOA as PNC). Narrow spectrum; Penicillinase resistant b/c of bulkier R-group
3) Hypersensitivity rxns

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6
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ampicillin

A

1) Extended-spectrum PNC–Haemophilus influenza, E. Coli, Listeria monocytogenes, Proteus mirabilis, Salmonella, Shigella, enterococci (HELPSS kill enterococci)
2) AminoPNCs; Bind PNC-binding proteins; Block
transpeptidase cross-linking of peptidoglycan; Activates autolytic
enzymes (=Same MOA as PNC). Wider spectrum; Penicillinase sensitive. Also combine w/ clavulonic acid to protect against Beta-lactamase.
3) Hypersensitivity rxs; Ampicillin rash; Pseudomemranous colitis
4) Resistance: Beta-lactamases cleave Beta-lactam ring

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7
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Amoxicillin

A

1) Extended-spectrum PNC–Haemophilus influenza, E. Coli, Listeria
monocytogenes, Proteus mirabilis, Salmonella, Shigella, enterococci (HELPSS kill enterococci)
2) AminoPNCs; Bind PNC-binding proteins; Block
transpeptidase cross-linking of peptidoglycan; Activates autolytic enzymes (=Same MOA as PNC). Wider spectrum; Penicillinase sensitive. Also combine w/ clavulonic acid to protect against Beta-lactamase.
3) Hypersensitivity rxs; Ampicillin rash; Pseudomemranous colitis
4) Resistance: Beta-lactamases cleave Beta-lactam ring; AmOxicillin has greater Oral bioavailability vs Ampicillin

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8
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ticarcillin

A

1) Pseudomonas spp. & gram-negative rods; Susceptible to penicillinase; Use w/ Clavulonic acid (to protect against Beta-lactamase)
2) Antipseudomonals; Bind PNC-binding proteins; Block
transpeptidase cross-linking of peptidoglycan; Activates autolytic
enzymes (=Same MOA as PNC). Extended spectrum
3) Hypersensitivity rxns
4) TCP (Ticarcillin, Carbenicillin, & Piperacillin)–Takes Care of Pseudomonas

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9
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Carbenicillin

A

1) Pseudomonas spp. & gram-negative rods; Susceptible to
penicillinase; Use w/ Clavulonic acid (to protect against Beta-lactamase)
2) Antipseudomonals; Bind PNC-binding proteins; Block
transpeptidase cross-linking of peptidoglycan; Activates autolytic
enzymes (=Same MOA as PNC). Extended spectrum
3) Hypersensitivity rxns
4) TCP (Ticarcillin, Carbenicillin, & Piperacillin)–Takes Care of Pseudomonas

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10
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Piperacillin

A

1) Pseudomonas spp. & gram-negative rods; Susceptible to
penicillinase; Use w/ Clavulonic acid (to protect against Beta-lactamase)
2) Antipseudomonals; Bind PNC-binding proteins; Block
transpeptidase cross-linking of peptidoglycan; Activates autolytic
enzymes (=Same MOA as PNC). Extended spectrum
3) Hypersensitivity rxns
4) TCP (Ticarcillin, Carbenicillin, & Piperacillin)–Takes Care of Pseudomonas

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11
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Clavulonic Acid

A

1) Often added to PNC abxs to protect the abx from destruction by Beta-lactamase (penicillinase)
2) Beta-lactamase inhibitor
3) –
4) CAST (Clavulonic Acid, Sulbactam, & Tazobactam)

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12
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Sulbactam

A

1) Often added to PNC abxs to protect the abx from destruction by Beta-lactamase (penicillinase)
2) Beta-lactamase inhibitor
3) –
4) CAST (Clavulonic Acid, Sulbactam, & Tazobactam)

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13
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tazobactam

A

1) Often added to PNC abxs to protect the abx from destruction by Beta-lactamase (penicillinase)
2) Beta-lactamase inhibitor
3) –
4) CAST (Clavulonic Acid, Sulbactam, & Tazobactam)

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14
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Cefazolin

A

1) Gram-positive cocci, Proteus mirabilis, E. Coli, Klebsiella pneumoniae. **Cefazolin–used prior to surgery to prevent S. aureus wound infections.
2) Beta-lactam, 1st Generation Cephalosporins; Beta-lactam rx that inhibits cell wall synthesis but are less susceptible to penicillinases. Bactericidal
3) Hypersensitivity rxns, Vit K deficiency. Low cross-reactivity w/ Penicillins. Increased nephrotoxicity of Aminoglycosides.
4) Orgs covered by 1st Generation=PEcK–Proteus mirabilis, E. Coli, Klebsiella pneumoniae; Orgs typically not covered by Cephalosporins are LAME: Listeria, Atypicals (Chlamydia, Mycoplasma), MRSA & Enterococci. (Exception= Ceftaroline-covers MRSA)

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15
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Cephalexin

A

1) Gram-positive cocci, Proteus mirabilis, E. Coli, Klebsiella pneumoniae
2) Beta-lactam, 1st Generation Cephalosporins; Beta-lactam rx that inhibits cell wall
synthesis but are less susceptible to penicillinases. Bactericidal
3) Hypersensitivity rxns, Vit K deficiency. Low cross-reactivity w/ Penicillins. Increased nephrotoxicity of Aminoglycosides.
4) Orgs covered by 1st Generation=PEcK–Proteus mirabilis, E. Coli, Klebsiella pneumoniae; Organisms typically not covered by Cephalosporins are LAME: Listeria, Atypicals (Chlamydia, Mycoplasma), MRSA & Enterococci. (Exception= Ceftaroline-covers MRSA)

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16
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Cefoxitin

A

1) Gram-positive cocci, Haemophilus influenzae, Enterobacter aerogenes, Neisseria spp., Proteus mirabilis, E. Coli, Klebsiella pneumoniae, Serratia marcescens
2) Beta-lactam, 2nd Generation Cephalosporins; Beta-lactam rx that inhibits cell wall synthesis but are less susceptibl to penicillinases. Bactericidal
3) Hypersensitivity rxns, Vit K deficiency. Low cross-reactivity w/ Penicillins. Increased nephrotoxicity of Aminoglycosides.
4) Orgs covered by 2nd Generation=HEN PEcKS–Haemophilus influenzae, Enterobacter aerogenes, Neisseria spp., Proteus
mirabilis, E. Coli, Klebsiella pneumoniae, Serratia marcescens; Organisms typically not covered by Cephalosporins are LAME: Listeria,
Atypicals (Chlamydia, Mycoplasma), MRSA & Enterococci. (Exception= Ceftaroline-covers MRSA)

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17
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Cefaclor

A

1) Gram-positive cocci, Haemophilus influenzae, Enterobacter aerogenes,
Neisseria spp., Proteus mirabilis, E. Coli, Klebsiella pneumoniae,
Serratia marcescens
2) Beta-lactam, 2nd Generation Cephalosporins; Beta-lactam rx that inhibits cell wall
synthesis but are less susceptibl to penicillinases. Bactericidal
3) Hypersensitivity rxns, Vit K deficiency. Low cross-reactivity w/ Penicillins. Increased nephrotoxicity of Aminoglycosides.
4) Orgs covered by 2nd Generation=HEN PEcKS–Haemophilus influenzae, Enterobacter aerogenes, Neisseria spp., Proteus
mirabilis, E. Coli, Klebsiella pneumoniae, Serratia marcescens; Organisms typically not covered by Cephalosporins are LAME: Listeria,
Atypicals (Chlamydia, Mycoplasma), MRSA & Enterococci. (Exception= Ceftaroline-covers MRSA)

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18
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Cefuroxime

A

1) Gram-positive cocci, Haemophilus influenzae, Enterobacter aerogenes,
Neisseria spp., Proteus mirabilis, E. Coli, Klebsiella pneumoniae,
Serratia marcescens
2) Beta-lactam, 2nd Generation Cephalosporins; Beta-lactam rx that inhibits cell wall
synthesis but are less susceptibl to penicillinases. Bactericidal
3) Hypersensitivity rxns, Vit K deficiency. Low cross-reactivity w/ Penicillins. Increased nephrotoxicity of Aminoglycosides.
4) Orgs covered by 2nd Generation=HEN PEcKS–Haemophilus influenzae, Enterobacter aerogenes, Neisseria spp., Proteus
mirabilis, E. Coli, Klebsiella pneumoniae, Serratia marcescens; Organisms typically not covered by Cephalosporins are LAME: Listeria,
Atypicals (Chlamydia, Mycoplasma), MRSA & Enterococci. (Exception=
Ceftaroline-covers MRSA)

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19
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ceftriaxone

A

1) Serious gram-negative infections resistant to other Beta-lactams; **Ceftriaxone–meningitis & gonorrhea
2) Beta-lactam, 3rd Generation Cephalosporins; Beta-lactam rx that inhibits cell wall
synthesis but are less susceptibl to penicillinases. Bactericidal
3) Hypersensitivity rxns, Vit K deficiency. Low cross-reactivity w/ Penicillins. Increased nephrotoxicity of Aminoglycosides.
4) Organisms typically not covered by Cephalosporins are LAME: Listeria,
Atypicals (Chlamydia, Mycoplasma), MRSA & Enterococci. (Exception=
Ceftaroline-covers MRSA)

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20
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Cefotaxime

A

1) Serious gram-negative infections resistant to other Beta-lactams
2) Beta-lactam, 3rd Generation Cephalosporins; Beta-lactam rx that inhibits cell wall
synthesis but are less susceptibl to penicillinases. Bactericidal
3) Hypersensitivity rxns, Vit K deficiency. Low cross-reactivity w/ Penicillins. Increased nephrotoxicity of Aminoglycosides.
4) Organisms typically not covered by Cephalosporins are LAME: Listeria,
Atypicals (Chlamydia, Mycoplasma), MRSA & Enterococci. (Exception=
Ceftaroline-covers MRSA)

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21
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ceftazidime

A

1) Serious gram-negative infections resistant to other Beta-lactams; **Ceftazidime–Pseudomonas.
2) Beta-lactam, 3rd Generation Cephalosporins; Beta-lactam rx that inhibits cell wall
synthesis but are less susceptibl to penicillinases. Bactericidal
3) Hypersensitivity rxns, Vit K deficiency. Low cross-reactivity w/ Penicillins. Increased nephrotoxicity of Aminoglycosides.
4) Organisms typically not covered by Cephalosporins are LAME: Listeria,
Atypicals (Chlamydia, Mycoplasma), MRSA & Enterococci. (Exception=
Ceftaroline-covers MRSA)

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22
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Cefepime

A

1) Increase activity against Pseudomonas & gram-positive orgs
2) Beta-lactam, 4th Generation Cephalosporins; Beta-lactam rx that inhibits cell wall
synthesis but are less susceptibl to penicillinases. Bactericidal
3) Hypersensitivity rxns, Vit K deficiency. Low cross-reactivity w/ Penicillins. Increased nephrotoxicity of Aminoglycosides.
4) Organisms typically not covered by Cephalosporins are LAME: Listeria,
Atypicals (Chlamydia, Mycoplasma), MRSA & Enterococci. (Exception= Ceftaroline-covers MRSA)

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23
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ceftaroline

A

1) **Only Cephalosporin that covers MRSA
2) Beta-lactam, **Newest Generation Cephalosporin; Beta-lactam rx that inhibits cell wall
synthesis but are less susceptibl to penicillinases. Bactericidal
3) Hypersensitivity rxns, Vit K deficiency. Low cross-reactivity w/ Penicillins. Increased nephrotoxicity of Aminoglycosides.
4) Organisms typically not covered by Cephalosporins are LAME: Listeria,
Atypicals (Chlamydia, Mycoplasma), MRSA & Enterococci. (Exception= Ceftaroline-covers MRSA)

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24
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ertapenem

A

1) Gram-positive cocci, gram-negative rods, & anaerobes. Wide spectrum, but the significant side effects limit use to life-threatening
infections, or after other drugs have failed.
2) Beta-lactam, Newer Carbapenem; Bind PNC-binding proteins; Block transpeptidase cross-linking of peptidoglycan; Activates autolytic enzymes (=Same MOA as PNC)
3) GI distress, Skin rash, & CNS toxicity (seizures) at high plasma levels

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25
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Doripenem

A

1) Gram-positive cocci, gram-negative rods, & anaerobes. Wide
spectrum, but the significant side effects limit use to life-threatening
infections, or after other drugs have failed.
2) Beta-lactam, Newer Carbapenem; Bind PNC-binding proteins; Block
transpeptidase cross-linking of peptidoglycan; Activates autolytic
enzymes (=Same MOA as PNC)
3) GI distress, Skin rash, & CNS toxicity (seizures) at high plasma levels

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26
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Aztreonam

A

1) Gram-negative rods only–No activity against gram-positives or anaerobes. For penicllin-allergic pts & those w/ renal insufficiency who cannot tolerate aminoglycosides
2) Beta-lactam, Monobactam; Resistant to Beta-lactamases. Prevents peptidoglycan cross-linking by binding to PBP3. Synergistic w/ Aminoglycosides. No cross-allergenicity w/ Penicillins.
3) Usually nontoxic; Occasional GI upset

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27
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Meropenem

A

1) Gram-positive cocci, gram-negative rods, & anaerobes. Wide spectrum, but the significant side effects limit use to life-threatening infections, or after other drugs have failed. **Meropenem, however, has a reduced risk of seizures & is stable to dehydropeptidase I.
2) Beta-lactam, Carbapenem; Bind PNC-binding proteins; Block transpeptidase cross-linking of peptidoglycan; Activates autolytic enzymes (=Same MOA as PNC)
3) GI distress, Skin rash, & CNS toxicity (seizures) at high plasma levels

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28
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Imipenem (w/ Cilastatin)

A

1) Gram-positive cocci, gram-negative rods, & anaerobes. Wide spectrum, but the significant side effects limit use to life-threatening
infections, or after other drugs have failed. *Meropenem, however, has a reduced risk of seizures & is stable to dehydropeptidase I.
2) Beta-lactam, Carbapenem; *Imipenem–broad-spectrum, Beta-lactamase-resistant carbapenem. Bind PNC-binding proteins; Block
transpeptidase cross-linking of peptidoglycan; Activates autolytic enzymes (=Same MOA as PNC). **Always administered w/ Cilastatin (inhib of renal dehydropeptidase I) to decrease inactivation of drug in renal tubules.
3) GI distress, Skin rash, & CNS toxicity (seizures) at high plasma level

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29
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Vancomycin

A

1) Gram-positive only–serious, amultidrug-resistant orgs, including MRSA, enterococci, & C. difficile (oral dose for pseudomembranous colitis)
2) Antimicrobial; Inhib cell wall peptidoglycan formation by binding D-ala D-ala portion of cell wall precursors. Bactericidal.
3) Nephrotoxicity, Ototoxicity, Thrombophlebitis, diffuse flushing–red man syndrome (can largely prevent by pretreatment w/ antihistamines & slow infusion rate). Well tolerated in general (–does NOT have many problems)
4) Resistance: Occurs w/ amino acid change of D-ala D-ala to D-ala D-lac. [“Pay back 2 D-alas (dollars) for VANdalizing (VANcomycin)]

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30
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Streptomycin

A

1) Severe gram-negative rod infections. Synergistic w/ Beta-lactam Abs.
2) Aminoglycoside; Bactericidal. Inhibits formation of initiation complex & cause misreading of mRNA. Also block translocation. Req O2 for uptake; therefore, ineffective against anaerobes. (A “initiates” the Alphabet)
3) Nephrotoxicity (esp when used w/ Cephalosporins), Neuromuscular blockade, Ototoxicity (esp when used w/ Loop diuretics). Teratogen.
4) Resistance: Transferase enzymes that inactivate the drug by acetylation, phosphorylation, or adenylation.
4) Aminoglycoside Rxs & ADES: “MEAN”=(aMINoglycosides) GNATS caNNOT kill anaerobes–Gentamicin, Neomycin, Amikacin, Tobramycin, Streptomycin, Nephrotox, Neuromuscular blockade, Ototoxicity, Teratogen

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31
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tobramycin

A

1) Severe gram-negative rod infections. Synergistic w/ Beta-lactam Abs.
2) Aminoglycoside; Bactericidal. Inhibits formation of initiation complex
& cause misreading of mRNA. Also block translocation. Req O2 for
uptake; therefore, ineffective against anaerobes. (A “initiates” the Alphabet)
3) Nephrotoxicity (esp when used w/ Cephalosporins),
Neuromuscular blockade, Ototoxicity (esp when used w/ Loop diuretics). Teratogen.
4) Resistance: Transferase enzymes that inactivate the drug by acetylation, phosphorylation, or adenylation.
4) Aminoglycoside Rxs & ADES: “MEAN”=(aMINoglycosides) GNATS caNNOT kill anaerobes–Gentamicin, Neomycin, Amikacin, Tobramycin, Streptomycin, Nephrotox, Neuromuscular blockade, Ototoxicity, Teratogen

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32
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Amikacin

A

1) Severe gram-negative rod infections. Synergistic w/ Beta-lactam Abs.
2) Aminoglycoside; Bactericidal. Inhibits formation of initiation complex
& cause misreading of mRNA. Also block translocation. Req O2 for
uptake; therefore, ineffective against anaerobes. (A “initiates” the Alphabet)
3) Nephrotoxicity (esp when used w/ Cephalosporins), Neuromuscular blockade, Ototoxicity (esp when used w/ Loop diuretics). Teratogen.
4) Resistance: Transferase enzymes that inactivate the drug by acetylation, phosphorylation, or adenylation.
4) Aminoglycoside Rxs & ADES: “MEAN”=(aMINoglycosides) GNATS caNNOT kill anaerobes–Gentamicin, Neomycin, Amikacin, Tobramycin, Streptomycin, Nephrotox, Neuromuscular blockade, Ototoxicity, Teratogen

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33
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Neomycin

A

1) Severe gram-negative rod infections. Synergistic w/ Beta-lactam Abs.; *Neomycin–for bowel surgery
2) Aminoglycoside; Bactericidal. Inhibits formation of initiation complex
& cause misreading of mRNA. Also block translocation. Req O2 for
uptake; therefore, ineffective against anaerobes. (A “initiates” the Alphabet)
3) Nephrotoxicity (esp when used w/ Cephalosporins), Neuromuscular blockade, Ototoxicity (esp when used w/ Loop diuretics). Teratogen.
4) Resistance: Transferase enzymes that inactivate the drug by acetylation, phosphorylation, or adenylation.
4) Aminoglycoside Rxs & ADES: “MEAN”=(aMINoglycosides) GNATS caNNOT
kill anaerobes–Gentamicin, Neomycin, Amikacin, Tobramycin, Streptomycin, Nephrotox, Neuromuscular blockade, Ototoxicity, Teratogen

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34
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Gentamicin

A

1) Severe gram-negative rod infections. Synergistic w/ Beta-lactam Abs.
2) Aminoglycoside; Bactericidal. Inhibits formation of initiation complex
& cause misreading of mRNA. Also block translocation. Req O2 for
uptake; therefore, ineffective against anaerobes. (A “initiates” the Alphabet)
3) Nephrotoxicity (esp when used w/ Cephalosporins), Neuromuscular blockade, Ototoxicity (esp when used w/ Loop diuretics). Teratogen.
4) Resistance: Transferase enzymes that inactivate the drug by acetylation, phosphorylation, or adenylation.
4) Aminoglycoside Rxs & ADES: “MEAN”=(aMINoglycosides) GNATS caNNOT kill anaerobes–Gentamicin, Neomycin, Amikacin, Tobramycin, Streptomycin, Nephrotox, Neuromuscular blockade, Ototoxicity, Teratogen

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35
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Minocycline

A

1) Borrelia burgdorferi, M. pneumoniae. Drug’s ability to accumulate intracellularly makes it very effective against Rickettsia & Chlamydia.
2) Tetracycline; Bacteriostatic. Bind to 30S & present attachment of aminoacyl-tRNA; Limited CNS penetration. Do not take w/ milk, antacids, or iron-containing preparations b/c divalent cations inhib its absorption in the gut
3) GI distress, Discoloration of teeth & inhib of bone growth in children, Photosensitivity. Contraindicated in pregnancy.
4) Resistance: Decreased uptake into cells or Increased efflus of cell by plasmid-encoded transport pumps.

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36
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Demeclocycline

A

1) Acts as diuretic in SIADH; *Rarely used as antibiotic (Role of abx= Borrelia burgdorferi, M. pneumoniae. Drug’s ability to accumulate intracellularly makes it very effective against Rickettsia & Chlamydia.)
2) Tetracycline; MOA in SIADH tx=ADH antagonist; MOA as abx=Bacteriostatic. Bind to 30S & present attachment of aminoacyl-tRNA; Limited CNS penetration. Do not take w/ milk, antacids, or iron-containing preparations b/c divalent cations inhib its absorption in the gut
3) GI distress, Discoloration of teeth & inhib of bone growth in children, Photosensitivity. Contraindicated in pregnancy.
4) Resistance: Decreased uptake into cells or Increased efflus of cell by plasmid-encoded transport pumps.

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37
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Doxycycline

A

1) Borrelia burgdorferi, M. pneumoniae. Drug’s ability to accumulate
intracellularly makes it very effective against Rickettsia & Chlamydia.
2) Tetracycline; Bacteriostatic. Bind to 30S & present attachment of aminoacyl-tRNA; Limited CNS penetration. *Doxycycline is fecally eliminated & can be used in pts w/ renal failure. Do not take w/ milk, antacids, or iron-containing preparations b/c divalent cations inhib its absorption in the gut
3) GI distress, Discoloration of teeth & inhib of bone growth in children, Photosensitivity. Contraindicated in pregnancy.
4) Resistance: Decreased uptake into cells or Increased efflus of cell by plasmid-encoded transport pumps.

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38
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tetracycline

A

1) Borrelia burgdorferi, M. pneumoniae. Drug’s ability to accumulate
intracellularly makes it very effective against Rickettsia &
Chlamydia.
2) Tetracycline; Bacteriostatic. Bind to 30S & present attachment of aminoacyl-tRNA; Limited CNS penetration. Do not take w/ milk, antacids, or iron-containing preparations b/c divalent cations inhib its absorption in the gut
3) GI distress, Discoloration of teeth & inhib of bone growth in children, Photosensitivity. Contraindicated in pregnancy.
4) Resistance: Decreased uptake into cells or Increased efflus of cell by plasmid-encoded transport pumps.

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39
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Erythromycin

A

1) Atypical pneumonias (Mycoplasma, Chlamydia, Legionella), STDs (for Chlamydia), & gram-positive cocci (Strep infections in pts allergic to penicillins)
2) Macrolide; Inhib protein synth by blocking translocation; Bind to 23S rRNA of 50S ribosomal subunit. Bacteriostatic.
3) Motility issues, Arrhythmia caused by prolonged QT, acute Cholecstatic hepatitis, Rash, eOsiniphilia (=MACRO). Increases serum concentration of theophyllines, oral anticoagulants.
4) Resistance: Methylation of 23S rRNA binding site.

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40
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Clarithromycin

A

1) Atypical pneumonias (Mycoplasma, Chlamydia, Legionella), STDs (for
Chlamydia), & gram-positive cocci (Strep infections in pts allergic
to penicillins)
2) Macrolide; Inhib protein synth by blocking translocation; Bind to 23S rRNA of 50S ribosomal subunit. Bacteriostatic.
3) Motility issues, Arrhythmia caused by prolonged QT, acute Cholecstatic
hepatitis, Rash, eOsiniphilia (=MACRO). Increases serum concentration of
theophyllines, oral anticoagulants.
4) Resistance: Methylation of 23S rRNA binding site.

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41
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Azithromycin

A

1) Atypical pneumonias (Mycoplasma, Chlamydia, Legionella), STDs (for
Chlamydia), & gram-positive cocci (Strep infections in pts allergic
to penicillins)
2) Macrolide; Inhib protein synth by blocking translocation; Bind to 23S rRNA of 50S ribosomal subunit. Bacteriostatic.
3) Motility issues, Arrhythmia caused by prolonged QT, acute Cholecstatic
hepatitis, Rash, eOsiniphilia (=MACRO). Increases serum concentration of
theophyllines, oral anticoagulants.
4) Resistance: Methylation of 23S rRNA binding site.

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42
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Chloramphenicol

A

1) Meningitis (Haemophius influenzae, Neisseria meningitidis, Streptococcus pneumoniae). Conservative use d/t toxicities but often still used in developing countries b/c of low cost
2) Protein Synthesis Inhib; Blocks peptidyltransfease at 50s ribosomal subunit. Bacteriostatic
3) Anemia (dose dep), Aplastic aneima (dose dep), Gray baby syndrome (in premature infants b/c lack liver UDP-glucuronyl transferase)
4) Resistance: Plasmid-encoded acetyltransferase that inactivates drug

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43
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Clindamycin

A

1) Anaerobic infections (e.g., Bacteroides fragilis, Clostridium perfringens) in aspiration pneumonia or lung abscesses. Also oroal infections w/ mouth anaerobes.
2) Protein Synthesis Inhib; Block peptide transfer (transpeptidation at 50s ribosomal subunit. Bacteriostatic.
3) Pseudomembranous colitis (C. dificile overgrowth), fever, diarrhea.
4) Clindamycin tx anaerobes ABOVE the diaphragm vs Metronidazole (which tx anaerobes BELOW the diaphragm)

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44
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Sulfadiazine

A

1) Gram-positive, gram-negative, Nocardia, Chlamydia. Triple sulfas or SMX for simple UTI.
2) Sulfonamides; PABA antimetabolites inhib dihydropteroate synthase. Bacteriostatic.
3) Hypersensitivity rxns, Hemolysis if G6PD deficient, Nephrotoxicity
(tubulointerstitial nephritis), Photosensitivity, Kernicterus in
infants, Displace other drugs from albumin (e.g. Warfarin)
4) Resistance: Altered enzyme (bacterial dihydropteroate synthase), Decreased uptake, or Increased PABA synthesis

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45
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Sulfisoxazole

A

1) Gram-positive, gram-negative, Nocardia, Chlamydia. Triple sulfas or SMX for simple UTI.
2) Sulfonamides; PABA antimetabolites inhib dihydropteroate synthase. Bacteriostatic.
3) Hypersensitivity rxns, Hemolysis if G6PD deficient, Nephrotoxicity
(tubulointerstitial nephritis), Photosensitivity, Kernicterus in
infants, Displace other drugs from albumin (e.g. Warfarin)
4) Resistance: Altered enzyme (bacterial dihydropteroate synthase), Decreased uptake, or Increased PABA synthesis

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46
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Sulfamethoxazole (SMX)

A

1) Gram-positive, gram-negative, Nocardia, Chlamydia. Triple sulfas or SMX for simple UTI.
2) Sulfonamides; PABA antimetabolites inhib dihydropteroate synthase. Bacteriostatic.
3) Hypersensitivity rxns, Hemolysis if G6PD deficient, Nephrotoxicity (tubulointerstitial nephritis), Photosensitivity, Kernicterus in infants, Displace other drugs from albumin (e.g. Warfarin)
4) Resistance: Altered enzyme (bacterial dihydropteroate synthase), Decreased uptake, or Increased PABA synthesis

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47
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Trimethoprim (TMP)

A

1) Used in combo w/ sulfonamides [trimethoprim-sulfamethoxazole (TMP-SMX)], causing sequential block of folate synth. This combination is used to tx: UTIs, Shigella, Salmonella, Pneumocystic jirovecii pneumonia (tx & prophylaxis)
2) Inhib bacterial dihydrofolate reductase. Bacteriostatic
3) Megaloblastic anemia, leukopenia, granulocytopenia. [May alleviate w/ supplemental folinic acid (=Leucovorin rescue)]
4) TMP–Treats Marrow Poorly

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48
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ciprofloxacin

A

1) Gram-negative rods of urinary & GI tracts (including Pseudomonas), Neisseria, some gram-positive orgs
2) Fluoroquinolone; Inhib DNA gyrase (topoisomerase II) & topoisomerase IV. Bacterocidal. Must not be taken w/ antacids.
3) GI upset, Super infections, Skin rashes, HA, Dizziness. Less comonly–tendonitis, tendon rupture, leg cramps, & myalgias. Contraindicated in–pregnant women & children b/c animal studies show damage to cartilage. Some may cause prolonged QT interal. May cause tendon rupture in ppl >60 yo & in pts taking Prednisone.
4) Resistance: Chromosome-encodede mut in DNA gyrase, plasmid-mediated resistance, efflux pumps

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49
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Norfloxacin

A

1) Gram-negative rods of urinary & GI tracts (including Pseudomonas), Neisseria, some gram-positive orgs
2) Fluoroquinolone; Inhib DNA gyrase (topoisomerase II) & topoisomerase IV. Bacterocidal. Must not be taken w/ antacids.
3) GI upset, Super infections, Skin rashes, HA, Dizziness. Less
comonly–tendonitis, tendon rupture, leg cramps, & myalgias.
Contraindicated in–pregnant women & children b/c animal studies
show damage to cartilage. Some may cause prolonged QT interal. May cause
tendon rupture in ppl >60 yo & in pts taking Prednisone.
4) Resistance: Chromosome-encodede mut in DNA gyrase, plasmid-mediated resistance, efflux pumps

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50
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Levofloxacin

A

1) Gram-negative rods of urinary & GI tracts (including Pseudomonas), Neisseria, some gram-positive orgs
2) Fluoroquinolone; Inhib DNA gyrase (topoisomerase II) & topoisomerase IV. Bacterocidal. Must not be taken w/ antacids.
3) GI upset, Super infections, Skin rashes, HA, Dizziness. Less
comonly–tendonitis, tendon rupture, leg cramps, & myalgias.
Contraindicated in–pregnant women & children b/c animal studies
show damage to cartilage. Some may cause prolonged QT interal. May cause
tendon rupture in ppl >60 yo & in pts taking Prednisone.
4) Resistance: Chromosome-encodede mut in DNA gyrase, plasmid-mediated resistance, efflux pumps

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51
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ofloxacin

A

1) Gram-negative rods of urinary & GI tracts (including Pseudomonas), Neisseria, some gram-positive orgs
2) Fluoroquinolone; Inhib DNA gyrase (topoisomerase II) & topoisomerase IV. Bacterocidal. Must not be taken w/ antacids.
3) GI upset, Super infections, Skin rashes, HA, Dizziness. Less
comonly–tendonitis, tendon rupture, leg cramps, & myalgias.
Contraindicated in–pregnant women & children b/c animal studies
show damage to cartilage. Some may cause prolonged QT interal. May cause
tendon rupture in ppl >60 yo & in pts taking Prednisone.
4) Resistance: Chromosome-encodede mut in DNA gyrase, plasmid-mediated resistance, efflux pumps

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52
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Sparfloxacin

A

1) Gram-negative rods of urinary & GI tracts (including Pseudomonas), Neisseria, some gram-positive orgs
2) Fluoroquinolone; Inhib DNA gyrase (topoisomerase II) & topoisomerase IV. Bacterocidal. Must not be taken w/ antacids.
3) GI upset, Super infections, Skin rashes, HA, Dizziness. Less
comonly–tendonitis, tendon rupture, leg cramps, & myalgias.
Contraindicated in–pregnant women & children b/c animal studies
show damage to cartilage. Some may cause prolonged QT interal. May cause
tendon rupture in ppl >60 yo & in pts taking Prednisone.
4) Resistance: Chromosome-encodede mut in DNA gyrase, plasmid-mediated resistance, efflux pumps

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53
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Moxifloxacin

A

1) Gram-negative rods of urinary & GI tracts (including Pseudomonas), Neisseria, some gram-positive orgs
2) Fluoroquinolone; Inhib DNA gyrase (topoisomerase II) & topoisomerase IV. Bacterocidal. Must not be taken w/ antacids.
3) GI upset, Super infections, Skin rashes, HA, Dizziness. Less
comonly–tendonitis, tendon rupture, leg cramps, & myalgias.
Contraindicated in–pregnant women & children b/c animal studies
show damage to cartilage. Some may cause prolonged QT interal. May cause
tendon rupture in ppl >60 yo & in pts taking Prednisone.
4) Resistance: Chromosome-encodede mut in DNA gyrase, plasmid-mediated resistance, efflux pumps

54
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Gatifloxacin

A

1) Gram-negative rods of urinary & GI tracts (including Pseudomonas), Neisseria, some gram-positive orgs
2) Fluoroquinolone; Inhib DNA gyrase (topoisomerase II) & topoisomerase IV. Bacterocidal. Must not be taken w/ antacids.
3) GI upset, Super infections, Skin rashes, HA, Dizziness. Less
comonly–tendonitis, tendon rupture, leg cramps, & myalgias.
Contraindicated in–pregnant women & children b/c animal studies
show damage to cartilage. Some may cause prolonged QT interal. May cause
tendon rupture in ppl >60 yo & in pts taking Prednisone.
4) Resistance: Chromosome-encodede mut in DNA gyrase, plasmid-mediated resistance, efflux pumps

55
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Enoxacin

A

1) Gram-negative rods of urinary & GI tracts (including Pseudomonas), Neisseria, some gram-positive orgs
2) Fluoroquinolone; Inhib DNA gyrase (topoisomerase II) & topoisomerase IV. Bacterocidal. Must not be taken w/ antacids.
3) GI upset, Super infections, Skin rashes, HA, Dizziness. Less
comonly–tendonitis, tendon rupture, leg cramps, & myalgias.
Contraindicated in–pregnant women & children b/c animal studies
show damage to cartilage. Some may cause prolonged QT interal. May cause
tendon rupture in ppl >60 yo & in pts taking Prednisone.
4) Resistance: Chromosome-encodede mut in DNA gyrase, plasmid-mediated resistance, efflux pumps

56
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Nalidixic acid

A

1) Gram-negative rods of urinary & GI tracts (including Pseudomonas), Neisseria, some gram-positive orgs
2) Quinolone; Inhib DNA gyrase (topoisomerase II) & topoisomerase IV. Bacterocidal. Must not be taken w/ antacids.
3) GI upset, Super infections, Skin rashes, HA, Dizziness. Less
comonly–tendonitis, tendon rupture, leg cramps, & myalgias.
Contraindicated in–pregnant women & children b/c animal studies
show damage to cartilage. Some may cause prolonged QT interal. May cause
tendon rupture in ppl >60 yo & in pts taking Prednisone.
4) Resistance: Chromosome-encodede mut in DNA gyrase, plasmid-mediated resistance, efflux pumps

57
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Metronidazole

A

1) Txs Giardia, Entamoeba, Trichomonas, Gardnerella vaginalis, Anaerobes (Bacteroides, C. dificile). Used w/ proton pump inhib & Clarithromycin for “triple therapy” against H. Pylori (GET GAP on the Metro w/ metronidazole!)
2) Forms free radical toxic metabolites in the bacterial cell that damage DNA. Bactericidal, antiprotozoal
3) Disulfuram-like rxn w/ alcohol; HA, Metallic taste

58
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Antimicrobial Drugs: Prophylaxis & Tx

  • M. tuberculosis
  • M. avium-intracelluare
  • M. leprae
A

Antimicrobial Drugs: Prophylaxis & Tx

  • M. tuberculosis–Prophylaxis=Isoniazid & Tx=Rifampin, Isoniazid, Pyrazinamide, Ethambutol (RIPE for tx)
  • M. avium-intracelluare–Prophylaxis=Azithromycin & Tx=Azithromycin, Rifampin, Ethanobutol, Streptomycin
  • M. leprae–Prophylaxis=N/A & Tx=Long-term tx w/ Dapsone & Rifampin for tuberculoid form. Add Clofazimine for lepromatous form.
59
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Isoniazid (INH)

A

1) Mycobacteriium tuberculosis; Only drug used as solo prophylaxis against TB
2) Antimicrobial; Decreases synth of mycolic acids. Bacterial catalase-peroxidases (KatG) needed to convert INH to active metabolite
3) Neurotoxicity, Hepatotoxicity. Pyridoxine (vit B6) can prevent neurotoxicity, lupus (INH–Injures Neurons & Hepatocytes)
4) Different INH half-lives in fast vs slow acetylator

60
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Rifampin

A

1) Mycobacterium tuburculosis; Delays resistance to dapsone when used for leprosy. Used for meningococcal prophylaxis and chemoprophylaxis in contacts of children w/ Haemophilus influenzae type B
2) Antimicrobial; Inhib DNA-dep RNA polymerase
3) Minor hepatotoxicity & drug rxns (increased P-450); Orange body fluids (nonhazardous side effect)
4) 4 Rs–RNA polymerase inhib, Revs up microsomal P-450, Red/orange body fluids, Rapid resistance if used alone

61
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Pyrazinamide

A

1) Mycobacterium tuberculosis
2) Antimicrobial; Mech unknown–thought to acidify intracellular env via conversion to pyrazinoic acid. Effective in acidid pH of phagolysosomes, where TB engulfed by macs is found
3) Hyperuricemia, Hepatotoxicity

62
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ethambutol

A

1) Mycobacterium tuberculosis
2) Antimicrobial; Decreases carbohydrate polymerization of mycobacterum cell wall by blocking arabinosyltransferase
3) optic neuropathy (red-green color blindness)

63
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Antimicrobial Prophylaxis:

-Meningococcal infection

A
  • Ciprofloxacin (Rx of choice)

- Rifampin for children

64
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Antimicrobial Prophylaxis:

-Gonorrhea

A

-Ceftriaxone

65
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Antimicrobial Prophylaxis:

-Syphilis

A

-Benzathine penicllin G

66
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Antimicrobial Prophylaxis:

-History of recurrent UTIs

A

-TMP-SMX

67
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Antimicrobial Prophylaxis:

-Endocarditis w/ surgical or dental procedures

A

-Penicillins

68
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Antimicrobial Prophylaxis:

-Pregnant woman carrying group B strep

A

-Ampicillin

69
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Antimicrobial Prophylaxis:

-Strep pharyngitis in child w/ prior rheumatic fever

A

-Oral penicllin

70
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Antimicrobial Prophylaxis:

-Prevention of postsurgical infection due to S. aureus

A

-Cefazolin

71
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Antimicrobial Prophylaxis:

-Prevention of gonococcal or chlamydial conjunctivitis in newborn

A

-Erythromycin ointment

72
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

HIV: Prophylaxis Tx & Infection

  • CD4 < 200 cells/mm3
  • CD4 < 100 cells/mm3
  • CD4 < 50 cells/mm3
A

HIV Prophylaxis Tx & Infection:

  • CD4 < 200 cells/mm3=*TMP-SMX; Pneumocytis pneumonia
  • CD4 < 100 cells/mm3=*TMP-SMX=Pneumocytis pneumona & Toxoplasmosis
  • CD4 < 50 cells/mm3=Azithromycin; Mycobacterium avium complex

*Aerosolized Pentamidine–can be used if pt is unable to tolerate TMP-SMX, butt this may not prevent toxoplasmosis

73
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tx for highly resistant bacteria:

  • MRSA
  • VRE
A
  • MRSA tx = Vancomycin

- VRE tx =Linezolid & Streptogramins (quinupristin/dalfopristin)

74
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Amphotericin B

A

1) Serious systemic mycoses, Cryptococcus (w or w/o Flucytosine for cryptococcal meningitis), Blastomyces, Coccidioides, Histoplasma, Candida, Mucor. Intrathecally for fungal meningitis.
2) Antifungal; Alters membrane fnx–Binds ergosterol (unique to fungi), forms membrane pores that allow leakage of electrolytes (AmphoTERicin “TEARs” holes in fungal membrane)
3) Fever/chills (“shake & bake”), Hypotension, Nephrotoxicity, Arrhythmias, Anemia, IV phlebitis (“AMPHOTERRIble); Hydration reduces nephrotoxicity (see line #4); Liposomal Amphotericin reduced toxicity
4) Supplement K & Mg b/c of altered renal tubule permeability

75
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Nystatin

A

1) “Swish & swallow” for oral candidiasis (thrush); Topical for diaper rash or vaginal candidiasis
2) Antifungal; Same MOA as Amphotericin B [=Alters membrane fnx–Binds ergosterol (unique to fungi), forms membrane
pores that allow leakage of electrolytes (AmphoTERicin “TEARs” holes in
fungal membrane)]. Topical form b/c too toxic for systemic use

76
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Fluconazole

A

1) Local & Less serious systemic mycoses; Floconazole specific=Chronic suppression of cryptoccal meningitis in AIDs pts & candida infection of all types
2) Antifungal-Azole; Inhib fungal sterol (ergosterol) synth by inhib P-450 enzyme that converts lanostrerol to ergosterol
3) Testosterone synth inhib (gynecomastia) Liver dysfnx (inhib cytochrome P-450)

77
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ketoconazole

A

1) Local & Less serious systemic mycoses
2) Antifungal-Azole; Inhib fungal sterol (ergosterol) synth by inhib P-450 enzyme that converts lanostrerol to ergosterol
3) Testosterone synth inhib (gynecomastia, esp Ketoconazole) Liver dysfnx (inhib cytochrome P-450)

78
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Clotrimazole

A

1) Local & Less serious systemic mycoses; Clotrimazole (& Miconazole) specific=Topical fungal infections
2) Antifungal-Azole; Inhib fungal sterol (ergosterol) synth by inhib P-450 enzyme that converts lanostrerol to ergosterol
3) Testosterone synth inhib (gynecomastia) Liver dysfnx (inhib cytochrome P-450)

79
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Miconazole

A

1) Local & Less serious systemic mycoses; Miconazole (& Clotrimazole) specific=Topical fungal infections
2) Antifungal-Azole; Inhib fungal sterol (ergosterol) synth by inhib P-450 enzyme that converts lanostrerol to ergosterol
3) Testosterone synth inhib (gynecomastia) Liver dysfnx (inhib cytochrome P-450)

80
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Itraconazole

A

1) Local & Less serious systemic mycoses; Itraconazole specific=Tx for Bastomyces, Coccidiodes, & Histoplasma
2) Antifungal-Azole; Inhib fungal sterol (ergosterol) synth by inhib P-450 enzyme that converts lanostrerol to ergosterol
3) Testosterone synth inhib (gynecomastia) Liver dysfnx (inhib cytochrome P-450)

81
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Voriconazole

A

1) Local & Less serious systemic mycoses
2) Antifungal-Azole; Inhib fungal sterol (ergosterol) synth by inhib P-450 enzyme that converts lanostrerol to ergosterol
3) Testosterone synth inhib (gynecomastia) Liver dysfnx (inhib cytochrome P-450)

82
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Flucytosine

A

1) Tx of systemic fungal infections (esp. meningitis caused by Cryptococcus) in combo w/ Amphotericin B
2) Antifungal; Inhib DNA & RNA biosynth by conversion to 5-fluorouracil by cytosine deaminase
3) BM suppression

83
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Caspofungin

A

1) Invasive aspergilliosis, Candida
2) Antifungal; Inhib cell wall synth by inhibiting synth of Beta-glucan
3) GI upset, flushing (by histasmine release)

84
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Micafungin

A

1) Invasive aspergilliosis, Candida
2) Antifungal; Inhib cell wall synth by inhibiting synth of Beta-glucan
3) GI upset, flushing (by histasmine release)

85
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Terbinafine

A

1) Tx dermatophytoses (esp onchomycosis=fungal infection of finger or toe nails)
2) Antifungal; Inhib fungal enzyme squalene epoxidase
3) Abn LFTs, Visual disturbances

86
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Griseofulvin

A

1) PO tx of superficial infections; Inhib growth of dermatophytes (tinea, ringworm)
2) Antifungal; Interferes w/ microtubule fnx; Disrupts mitosis. Deposits in keratin-containing tissues (e.g. nails)
3) Teratogenic, Carinogenic, Confusion, HAs, Increase P-450 & warfarin metabolism

87
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Pyrimethamine

A

1) Tx Toxoplasmosis

2) Antiprotozoan

88
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Suramin

A

1) Tx Trypanosoma brucei

2) Antiprotozoan

89
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Melarsoprol

A

1) Tx Trypanosoma brucei

2) Antiprotozoan

90
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Nifurtimox

A

1) Tx Trypansoma cruzi

2) Antiprotozoan

91
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Sodium stibogluconate

A

1) Tx Leishmaniasis

2) Antiprotozoan

92
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Chloroquine

A

1) Tx of plasmodial species other than P. falciparium ( d/t high resistance; see line #4)
2) Blocks detoxification of heme into hemozoin. Heme accumulates and is toxic to plasmodia
3) Retinopathy
4) P. falciparum mechanism of resistance: Membrane pump that decreases intracellular concentration of Chloroquine; Tx P. falciparum w/ Artemether/Lumifantrine OR Atovaquone/Proguanil; Tx life-threatening malaria w/ Quinidine in US (quinine elsewere) or Artisunate

93
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Txs for P. falciparum

A
  • Artemether/Lumifantrine OR Atovaquone/Proguanil

- NOT Chloroquine (d/t resistance)

94
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Txs for life-threatening malaria

A

-Quinidine in US (quinine elsewere) or Artisunate

95
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Mebendazole

A

2) Antihelminthic therapy; Immobilize helminths

96
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Pyrantel pamoate

A

2) Antihelminthic therapy; Immobilize helminths

97
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ivermectin

A

2) Antihelminthic therapy; Immobilize helminths

98
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Diethylcarbamazine

A

2) Antihelminthic therapy; Immobilize helminths

99
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Praziquantel

A

1) Tx for flukes (trematodes, e.g. Schistosoma)

2) Antihelminthic therapy; Immobilize helminths

100
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Zanamivir

A

1) Tx and prevention of: Influenza A & B

2) Antiviral therapy; Inhib influenza neuraminidase, Decreasing the release of pogeny virus

101
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Oseltmavir

A

1) Tx and prevention of: Influenza A & B

2) Antiviral therapy; Inhib influenza neuraminidase, Decreasing the release of pogeny virus

102
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ribavirin

A

1) RSV, Chronic hepatitis C
2) Antiviral therapy; Inhib synth of guanine nucleotides by competitively inhibiting IMP dehydrogenase
3) Hemolytic anemia, Severe teratogen

103
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Acyclovir

A

1) HSV & ZVZ; Weak activity against EBV. No activity against CMV. Used for HSZ-induced mucocutaneous & genital lesions as well as encephalitis. Prophylaxis in immunocompromised pts. No effect on latent forms of HSZ & ZVZ.
2) Antiviral therapy; Monophosphorylated by HSV/VZV thymidine kinase. Guanosine analog. Triphosphate formed by cellular enzymes. Preferentially inihib viral DNA polymerase by chain termination
4) Mechanism of resistance: Mutated viral thymidine kinase

104
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Valacyclovir

A

1) HSV & ZVZ; Weak activity against EBV. No activity against CMV. Used for HSZ-induced mucocutaneous & genital lesions as well as encephalitis. Prophylaxis in immunocompromised pts. No effect on latent
forms of HSZ & ZVZ.
2) Antiviral therapy; = a prodrug of Acyclovir, so has better oral bioavailability vs Acyclovir Monophosphorylated by HSV/VZV thymidine kinase. Guanosine analog. Triphosphate formed by cellular enzymes. Preferentially inihib viral DNA polymerase by chain termination
4) Mechanism of resistance: Mutated viral thymidine kinase

105
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Famciclovir

A

1) Herpes Zoster

2) Antiviral therapy; Related to Acyclovir

106
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ganciclovir

A

1) CMV, esp in immunocompromised pts.
2) Antiviral therapy; 5’-monophosphate formed CMV viral kinase Guanosine analog. Triphosphate formed by cellular kinases. Preferentially inhib viral DNA polymerase
3) Leukopenia, Neutropenia, Thrombocytopenia, Renal toxicity; More toxic to host enzymes vs Acyclovir
4) Mechanism of resistance: Mutated CMV DNA polymerase or lack of viral kinase

107
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Valganciclovir

A

1) CMV, esp in immunocompromised pts.
2) Antiviral therapy; a prodrug of Ganciclovir, so has better ora bioavailability vs Ganciclovir 5’-monophosphate formed CMV viral kinase Guanosine analog. Triphosphate formed by cellular kinases. Preferentially inhib viral DNA polymerase
3) Leukopenia, Neutropenia, Thrombocytopenia, Renal toxicity; More toxic to host enzymes vs Acyclovir
4) Mechanism of resistance: Mutated CMV DNA polymerase or lack of viral kinase

108
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Foscarnet

A

1) CMV retinitis in immunocompromised pts when Ganciclovir fails; Acyclovir-resistant HSV
2) Antiviral therapy; A pyrophosphate analog (Foscarnet=pyroFOSphate analog). Viral DNA polymerase inhib that binds to pyrophosphate-binding site of the enzyme. Does not req activation by viral kinase
3) Nephrotoxicity
4) Mechanism of resistance: Mutated DNA polymerase

109
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Cidofovir

A

1) CMV retinitis in immunocompromised pts; Acyclovir-resistant HSV
2) Antiviral therapy; Preferentially inhib viral DNA polymerase. Does not req phosphorylation by viral kinase. Long t-1/2.
3) Nephrotoxicity (co-admin w/ Probenecid & IV saline to reduce toxicity)

110
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

HIV Therapy:

  • Name
  • When to initiate
  • Drug regimen
A

-Highly active antiretroviral therapy (HAART)
-Initiate when pts present w/ AIDS-defining illness, low CD4+ cts (<500 cells/mm3), or high viral load
-Regimen consists of (3) drugs to prevent resistance:
–2 nucleoside reverse transcriptase inhib (NRTIs)
+
–1 non-nucleoside reverse transcriptase inhib (NNRTI) OR 1 protease inhib OR 1 integrase inhib

111
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Lopinavir

A

1) HIV therapy
2) Protease inhib; Prevents maturation of new viruses by cleaving HIV-1 protease (Assembly of virions depends on HIV-1 protease, which cleaves polypeptide products of HIV mRNA into their functional parts)
3) Hyperglycemia, GI intolerance (N/D), Lipodystrophy, Nephropathy
4) All protease inhibitors end in -navir [ Navir (never) tease a protease]

112
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Atazanavir

A

1) HIV therapy
2) Protease inhib; Prevents maturation of new viruses
by cleaving HIV-1 protease (Assembly of virions depends on HIV-1
protease, which cleaves polypeptide products of HIV mRNA into their
functional parts)
3) Hyperglycemia, GI intolerance (N/D), Lipodystrophy, Nephropathy
4) All protease inhibitors end in -navir [ Navir (never) tease a protease]

113
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Darunavir

A

1) HIV therapy
2) Protease inhib; Prevents maturation of new viruses
by cleaving HIV-1 protease (Assembly of virions depends on HIV-1
protease, which cleaves polypeptide products of HIV mRNA into their
functional parts)
3) Hyperglycemia, GI intolerance (N/D), Lipodystrophy, Nephropathy
4) All protease inhibitors end in -navir [ Navir (never) tease a protease]

114
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Fosaprenavir

A

1) HIV therapy
2) Protease inhib; Prevents maturation of new viruses
by cleaving HIV-1 protease (Assembly of virions depends on HIV-1
protease, which cleaves polypeptide products of HIV mRNA into their
functional parts)
3) Hyperglycemia, GI intolerance (N/D), Lipodystrophy, Nephropathy
4) All protease inhibitors end in -navir [ Navir (never) tease a protease]

115
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Saquinavir

A

1) HIV therapy
2) Protease inhib; Prevents maturation of new viruses
by cleaving HIV-1 protease (Assembly of virions depends on HIV-1
protease, which cleaves polypeptide products of HIV mRNA into their
functional parts)
3) Hyperglycemia, GI intolerance (N/D), Lipodystrophy, Nephropathy
4) All protease inhibitors end in -navir [ Navir (never) tease a protease]

116
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Ritonavir

A

1) HIV therapy
2) Protease inhib; Prevents maturation of new viruses
by cleaving HIV-1 protease (Assembly of virions depends on HIV-1
protease, which cleaves polypeptide products of HIV mRNA into their
functional parts)
3) Hyperglycemia, GI intolerance (N/D), Lipodystrophy, Nephropathy
4) All protease inhibitors end in -navir [ Navir (never) tease a protease]; Ritonavir specific=CYP450 inhib

117
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Indinavir

A

1) HIV therapy
2) Protease inhib; Prevents maturation of new viruses
by cleaving HIV-1 protease (Assembly of virions depends on HIV-1
protease, which cleaves polypeptide products of HIV mRNA into their
functional parts)
3) Hyperglycemia, GI intolerance (N/D), Lipodystrophy, Nephropathy; Indinavir specific ADE=Hematuria
4) All protease inhibitors end in -navir [ Navir (never) tease a protease]

118
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Tenofovir (TDF)

A

1) HIV therapy
2) Nucleoside reverse transcriptase inhib (NRTI); Completely inhib nucleotide binding to reverse transcriptase & terminate te DNA chain (lack a 3’ OH group)
3) BM suppression (can be reversed w/ G-CSF & EPO), Peripheral neuropathy, Lactic Acidosis
4) Is a nucleotide analog, so does not have to be activated (vs other NRTIs, which are nucleoside analogs & therefore, req activation)

119
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Emtricitabine (FTC)

A

1) HIV therapy
2) Nucleoside reverse transcriptase inhib (NRTI);
Completely inhib nucleotide binding to reverse transcriptase &
terminate te DNA chain (lack a 3’ OH group)
3) BM suppression (can be reversed w/ G-CSF & EPO), Peripheral neuropathy; Lactic acidosis
4) Must be phosphorylated to be activated (True of all NRTIs, except Tenofovir b/c it is a nucleotide vs nucleoside analog)

120
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Abacavir (ABC)

A

1) HIV therapy
2) Nucleoside reverse transcriptase inhib (NRTI);
Completely inhib nucleotide binding to reverse transcriptase &
terminate te DNA chain (lack a 3’ OH group)
3) BM suppression (can be reversed w/ G-CSF & EPO), Peripheral neuropathy; Lactic acidosis
4) Must be phosphorylated to be activated (True of all NRTIs, except Tenofovir b/c it is a nucleotide vs nucleoside analog)

121
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Lamivudine (3TC)

A

1) HIV therapy
2) Nucleoside reverse transcriptase inhib (NRTI);
Completely inhib nucleotide binding to reverse transcriptase &
terminate te DNA chain (lack a 3’ OH group)
3) BM suppression (can be reversed w/ G-CSF & EPO), Peripheral neuropathy; Lactic acidosis
4) Must be phosphorylated to be activated (True of all NRTIs, except Tenofovir b/c it is a nucleotide vs nucleoside analog)

122
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Zidovudine (ZDV, formerly AZT)

A

1) HIV therapy
2) Nucleoside reverse transcriptase inhib (NRTI);
Completely inhib nucleotide binding to reverse transcriptase &
terminate te DNA chain (lack a 3’ OH group)
3) BM suppression (can be reversed w/ G-CSF & EPO), Peripheral neuropathy; Lactic acidosis; ZDZ specific ADE=Anemia
4) Used for general prophylaxis & during pregnancy to reduce risk of fetal transmission; Must be phosphorylated to be activated (the second statement is true of all NRTIs, except Tenofovir b/c it is a nucleotide vs nucleoside analog)

123
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Didanosine (ddl)

A

1) HIV therapy
2) Nucleoside reverse transcriptase inhib (NRTI);
Completely inhib nucleotide binding to reverse transcriptase &
terminate te DNA chain (lack a 3’ OH group)
3) BM suppression (can be reversed w/ G-CSF & EPO), Peripheral neuropathy; Lactic acidosis
4) Must be phosphorylated to be activated (True of all NRTIs, except Tenofovir b/c it is a nucleotide vs nucleoside analog)

124
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Stavudine (d4T)

A

1) HIV therapy
2) Nucleoside reverse transcriptase inhib (NRTI);
Completely inhib nucleotide binding to reverse transcriptase &
terminate te DNA chain (lack a 3’ OH group)
3) BM suppression (can be reversed w/ G-CSF & EPO), Peripheral neuropathy; Lactic acidosis
4) Must be phosphorylated to be activated (True of all NRTIs, except Tenofovir b/c it is a nucleotide vs nucleoside analog)

125
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Nevirapine

A

1) HIV therapy
2) Non-nucleoside reverse transcriptase inhib (NNRTI); Bind to reverse transcriptase at site different from NRTIs (Nucleoside RTIs). Do not req phosphorylation to be active or compete w/ nucleotides
3) BM suppression (can be reversed w/ G-CSF & EPO), Peripheral neuropathy; Rash

126
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Efazirenz

A

1) HIV therapy
2) Non-nucleoside reverse transcriptase inhib (NNRTI);
Bind to reverse transcriptase at site different from NRTIs (Nucleoside
RTIs). Do not req phosphorylation to be active or compete w/ nucleotides
3) BM suppression (can be reversed w/ G-CSF & EPO), Peripheral neuropathy; Rash

127
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Delavirdine

A

1) HIV therapy
2) Non-nucleoside reverse transcriptase inhib (NNRTI);
Bind to reverse transcriptase at site different from NRTIs (Nucleoside
RTIs). Do not req phosphorylation to be active or compete w/ nucleotides
3) BM suppression (can be reversed w/ G-CSF & EPO), Peripheral neuropathy; Rash

128
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Raltegravir

A

1) HIV therapy
2) Integrase inhib; Inhibits HIV genome integration into host cell chromosome by reversibly inhibiting HIV integrase
3) Hypercholesterolemia

129
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

IFN-Alpha

A

1) Chronic hepatitis B & C; Kaposi’s sarcoma
2) Interferon; Glycoproteins synth by virus-infected cells; Blocks replication of both RNA & DNA viruses
3) Neutropenia, Myopathy

130
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

IFN-Beta

A

1) MS
2) Interferon; Glycoproteins synth by virus-infected cells; Blocks replication of both RNA & DNA viruses
3) Neutropenia, Myopathy

131
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

IFN-Gamma

A

1) NADPH oxidase deficiency
2) Interferon; Glycoproteins synth by virus-infected cells; Blocks replication of both RNA & DNA viruses
3) Neutropenia, Myopathy

132
Q

1) uses 2) class/ MOA 3) ADE 4)Fun fact/note

Abx to avoid in pregnancy

A

Contraindicated in Pregnancy –> Adverse Effect:

  • Sulfonamides –> Kernicterus
  • Aminoglycosides –> Ototoxicity
  • Fluoroquinolones –> Cartolage damage
  • Clarithromycin –> Embryotoxic
  • Tetracyclines –> Discolored teeth, Inhib of bone growth
  • Ribavirin (antiviral) –> Teratogenic
  • Griseofulvin (antifungal) –> Teratogenic
  • Chloramphenicol –> “Gray baby”

(SAFe Children Take Really Good Care)

All the Drugs (17 decks)

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