Block 3 Opioids

Question 1

Morphine, Methadone, Meperidine/Pethidine, Heroin, “codone”, Fentanyl, “fentanil” (Full Agonist)

Answer 1

Effects: analgesic, sedation, resp dep, inc ICP, miosis, constipation, urine ret, dec clearance of biliary stones

Question 2

Codeine, Buprenorphine, Nalbuphine, Pentazocine (Partial Agonist)

Answer 2

Codeine: anti-tussive/ cough supplement
Dextrometorphan: non-opioid cough suppressant

Question 3

Naltrexone/Naloxone (Opioid Receptor Antagonist)

Answer 3

Naltrexone: oral, used for alcohol, opioid abuse or dependence
Naloxone: IV, used for opioid overdose

Question 4

Morphine

Answer 4

low bioavail, releases histamine to cause vasodil, inc GH, prolactin, ADH,
can treat Pulm Edema

Question 5

Methadone

Answer 5

Longer t1/2
slow onset
good oral avail

Question 6

Opioid Addiction Program

Answer 6

Methadone-FA
Buprenorphine-PA
Naltrexone

Question 7

Meperidine/Pethidine

Answer 7

M-block (no pinpoint pupils/spasms)

DI: use w/ SSRI’s causes Serotonin Syndrome